Introduction：Basic information about CAS 1174046-72-0|BMS-794833, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BMS-794833 |
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| CAS Number | 1174046-72-0 | Molecular Weight | 468.840 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 637.2±55.0 °C at 760 mmHg |
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| Molecular Formula | C23H15ClF2N4O3 | Melting Point | / |
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| MSDS | / | Flash Point | 339.2±31.5 °C |
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Names
| Name | N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide |
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| Synonym | More Synonyms |
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BMS-794833 BiologicalActivity
| Description | BMS-794833 is a VEGFR2 and Met inhibitor extracted from patent WO2009094417, compound example 1; has IC50s of 15 and 1.7 nM, respectively. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>c-Met/HGFRResearch Areas >>Cancer |
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| Target | VEGFR2:15 nM (IC50) Met:1.7 nM (IC50) |
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| In Vitro | BMS794833 inhibits Met receptor activated gastric carcinoma cell line, GTL-16, with an IC50 of 39 nM[1]. |
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| In Vivo | BMS-794833 is active by greater than 50% tumor growth inhibition for at least one tumor doubling time in the GTL-16 gastric carcinoma model. No toxicity is observed at any of the dose levels when administered once daily for a duration of 14 days[1]. |
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| Cell Assay | GTL-16 cells are inoculated in to 96 well microtiter plates in 0.5% fetal calf serum and incubated at 37°C, 5% CO2, 95% air and 100% relative humidity for 24 h prior to addition of a compound. Cells are treated with BMS-794833 for an additional 72 h. Growth inhibition is calculated[1]. |
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| References | [1]. WO2009094417 |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 637.2±55.0 °C at 760 mmHg |
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| Molecular Formula | C23H15ClF2N4O3 |
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| Molecular Weight | 468.840 |
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| Flash Point | 339.2±31.5 °C |
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| Exact Mass | 468.080078 |
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| PSA | 114.32000 |
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| LogP | 4.26 |
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| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
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| Index of Refraction | 1.681 |
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| Storage condition | -20℃ |
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Synonyms
| 3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo- |
| N-{4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl}-5-(4-fluorophenyl)-4-oxo-1,4-dihydro-3-pyridinecarboxamide |
| BMS-794833 |
