CAS 1228182-50-0|BaquilopriM-D6
Introduction：Basic information about CAS 1228182-50-0|BaquilopriM-D6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BaquilopriM-D6 | ||
|---|---|---|---|
| CAS Number | 1228182-50-0 | Molecular Weight | 314.42 |
| Density | / | Boiling Point | / |
| Molecular Formula | C17H14D6N6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 5-[[8-[bis(trideuteriomethyl)amino]-7-methylquinolin-5-yl]methyl]pyrimidine-2,4-diamine |
|---|---|
| Synonym | More Synonyms |
BaquilopriM-D6 BiologicalActivity
| Description | Baquiloprim-d6 is deuterium labeled Baquiloprim. Baquiloprim, an antibiotic, is a selective inhibitor of bacterial dihydrofolate reductases. Baquiloprim possesses in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria[1][2]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Lewicki J, et, al. Oral bioavailability and pharmacokinetics of baquiloprim in dwarf goats. Res Vet Sci. 1995 May;58(3):268-71. [3]. White DG, et, al. Comparison of danofloxacin with baquiloprim/sulphadimidine for the treatment of experimentally induced Escherichia coli diarrhoea in calves. Vet Rec. 1998 Sep 5;143(10):273-6. |
Chemical & Physical Properties
| Molecular Formula | C17H14D6N6 |
|---|---|
| Molecular Weight | 314.42 |
| Exact Mass | 314.21300 |
| PSA | 95.41000 |
| LogP | 2.01460 |
| InChIKey | AIOWJIMWVFWROP-XERRXZQWSA-N |
| SMILES | Cc1cc(Cc2cnc(N)nc2N)c2cccnc2c1N(C)C |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Phrases | 22-36/37/38 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
Synonyms
| 5-{[8-(Dimethylamino-d6)-7-methyl-5-quinolinyl]methyl}-2,4-pyrimidinediamine |
| Baquiloprim-d6 |
