Introduction：Basic information about CAS 129-67-9|Demethylcantharidate disodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Demethylcantharidate disodium |
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| CAS Number | 129-67-9 | Molecular Weight | 230.13 |
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| Density | / | Boiling Point | 447.8ºC at 760 mmHg |
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| Molecular Formula | C8H8Na2O5 | Melting Point | / |
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| MSDS | / | Flash Point | 190.5ºC |
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Names
| Name | endothal-disodium |
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| Synonym | More Synonyms |
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Demethylcantharidate disodium BiologicalActivity
| Description | Demethylcantharidate disodium, an endogenous metabolite, induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Metabolic Disease |
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| In Vitro | Demethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours) disodium inhibits HCC cell proliferation[1]. Demethylcantharidate (0, 9, 18 or 36 µM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2[1]. Cell Viability Assay[1] Cell Line: HCC cell lines (SMMC-7721 and Bel-7402) Concentration: 0-100 μM Incubation Time: 0, 12, 24, 48 or 72 hours Result: Showed anti-proliferative activity in the two HCC cell lines. Cell Viability Assay[1] Cell Line: HCC cells Concentration: 0, 9, 18 or 36 µM Incubation Time: 24 hours Result: Induced apoptosis in HCC cells via the intrinsic pathway. |
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| In Vivo | Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo[1]. |
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| References | [1]. Ye M, et al. Sodium demethylcantharidate induces apoptosis in hepatocellular carcinoma cells via ER stress. Am J Transl Res. 2019;11(5):3150-3158. Published 2019 May 15. |
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Chemical & Physical Properties
| Boiling Point | 447.8ºC at 760 mmHg |
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| Molecular Formula | C8H8Na2O5 |
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| Molecular Weight | 230.13 |
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| Flash Point | 190.5ºC |
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| Exact Mass | 230.01700 |
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| PSA | 89.49000 |
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| Vapour Pressure | 2.88E-09mmHg at 25°C |
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| InChIKey | XRHVZWWRFMCBAZ-UHFFFAOYSA-L |
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| SMILES | O=C([O-])C1C2CCC(O2)C1C(=O)[O-].[Na+].[Na+] |
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Safety Information
| Risk Phrases | 21-25-36/37/38 |
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| RIDADR | UN 2588 |
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| Packaging Group | II |
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| Hazard Class | 6.1(a) |
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Synonyms
| disodium 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate |
| disodium demethylcantharate |
| endothal |
| disodium,7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate |
| endothal-sodium |
| Disodium endothall |
| disodium endothallate |
| Accelerate |
| Endothal-sodium |
| Endothal-disodium |
| disodium (1Ξ,2Ξ,3Ξ,4Ξ)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate |
| Endothall sodium |
| Endothall disodium salt |
| Caswell No. 421C |
| endothall sodium |
| Ripenthol |
| Natriicantharidas |
| Aguathol |
