CAS 140926-75-6|NSC5844

Introduction：Basic information about CAS 140926-75-6|NSC5844, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. NSC5844 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	NSC5844
CAS Number	140926-75-6	Molecular Weight	383.27400
Density	/	Boiling Point	/
Molecular Formula	C₂₀H₁₆Cl₂N₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine
Synonym	More Synonyms

NSC5844 BiologicalActivity

Description	NSC5844 is a 4-aminoquinoline derivative, with antitumor and antimalarial activity.
Related Catalog	Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>CancerResearch Areas >>Infection
Target	Parasite[2]
In Vitro	NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI50s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively[1]. NSC5844 (Compound 1) is cytotoxic to P. falciparum, inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum, with IC50s of 17 and 27 nM, respectively[2].
References	[1]. Zhang H, et al. Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Biomed Pharmacother. 2008 Feb;62(2):65-9. Epub 2007 May 24. [2]. Vennerstrom JL, et al. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria. J Med Chem. 1992 May 29;35(11):2129-34.

Chemical & Physical Properties

Molecular Formula	C₂₀H₁₆Cl₂N₄
Molecular Weight	383.27400
Exact Mass	382.07500
PSA	49.84000
LogP	5.75980
InChIKey	SSXYXSMMVMVYEV-UHFFFAOYSA-N
SMILES	Clc1ccc2c(NCCNc3ccnc4cc(Cl)ccc34)ccnc2c1

Safety Information

Hazard Codes	Xi

Synonyms

N,N'-Bis-(7-chlor-[4]chinolyl)-aethylendiamin

1,2-Ethanediamine,N,N'-bis(7-chloro-4-quinolinyl)

N,N'-bis-(7-chloro-[4]quinolyl)-ethylenediamine

N1,N2-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine

NSC5844

RE640

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