CAS 432-60-0|Allylestrenol

Introduction：Basic information about CAS 432-60-0|Allylestrenol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Allylestrenol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Allylestrenol
CAS Number	432-60-0	Molecular Weight	300.478
Density	1.0±0.1 g/cm3	Boiling Point	405.4±44.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₂O	Melting Point	78 - 81ºC
MSDS	/	Flash Point	170.6±20.7 °C

Names

Name	Allylestrenol
Synonym	More Synonyms

Allylestrenol BiologicalActivity

Description	Allylestrenol, a synthetic sexualsteroid, is used worldwide in case of endangered pregnancies.
Related Catalog	Research Areas >>EndocrinologySignaling Pathways >>Others >>Others
References	[1]. Pap E, et al. Effect of prenatal allylestrenol treatment (hormonal imprinting) on the serum testosterone and progesterone level in adult rats. Gen Pharmacol. 1995 Mar;26(2):365-7.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	405.4±44.0 °C at 760 mmHg
Melting Point	78 - 81ºC
Molecular Formula	C₂₁H₃₂O
Molecular Weight	300.478
Flash Point	170.6±20.7 °C
Exact Mass	300.245331
PSA	20.23000
LogP	6.64
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.553
InChIKey	ATXHVCQZZJYMCF-XUDSTZEESA-N
SMILES	C=CCC1(O)CCC2C3CCC4=CCCCC4C3CCC21C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG7960000

CHEMICAL NAME :: Estr-4-en-17-beta-ol, 17-allyl-

CAS REGISTRY NUMBER :: 432-60-0

BEILSTEIN REFERENCE NO. :: 3148038

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C21-H32-O

MOLECULAR WEIGHT :: 300.53

WISWESSER LINE NOTATION :: L E5 B666 MUTJ E1 FQ F2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,41,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8 mg/kg

SEX/DURATION :: female 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 9,57,1964

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 900 mg/kg

SEX/DURATION :: female 13-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 65,29,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 300 mg/kg

SEX/DURATION :: male 15 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 59,768,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 15 mg/kg

SEX/DURATION :: male 15 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 59,768,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 175 mg/kg

SEX/DURATION :: female 15-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 38,128,1961

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 900 mg/kg

SEX/DURATION :: female 13-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 65,29,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 2100 ug/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

REFERENCE :: JDPHDH Journal of Developmental Physiology. (Oxford University Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1979- Volume(issue)/page/year: 19,67,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 4500 ug/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 26,365,1995

Synonyms

allyloestrenol

17α-Allyl-4-oestrene-17β-ol

EINECS 207-082-9

organon

allyl-estreno

17-Allylestr-4-en-17b-ol

Estr-4-en-17β-ol, 17-allyl-

Estr-4-en-17-ol, 17-(2-propen-1-yl)-, (17β)-

(8R,9S,10R,13S,14S,17R)-17-Allyl-13-methyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol

17α-Allylestr-4-en-17β-ol

MFCD00198957

17-Hydroxy-17a-allyl-4-estrene

(17β)-17-(prop-2-en-1-yl)estr-4-en-17-ol

Estr-4-en-17-ol, 17-(2-propenyl)-, (17β)-

Estr-4-en-17-ol, 17- (2-propenyl)-, (17β)-

17α-Allyl-17β-hydroxy-4-estrene

Gestanin

(17β)-17-prop-2-en-1-ylestr-4-en-17-ol

17a-Allyl-17-hydroxy-19-nor-4-androstene

Turinal

allylestrenol

Orageston

17α-Allyl-4-estren-17β-ol

Gestanon

gestanyn

Gestanol

Recommended......