Introduction：Basic information about CAS 55285-14-8|Carbosulfan, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Carbosulfan |
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| CAS Number | 55285-14-8 | Molecular Weight | 380.545 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 462.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C20H32N2O3S | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 233.5±31.5 °C |
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| Symbol |
GHS06, GHS09 | Signal Word | Danger |
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Names
| Name | carbosulfan |
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| Synonym | More Synonyms |
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Carbosulfan BiologicalActivity
| Description | Carbosulfan inhibited relatively potently CYP3A4 and moderately CYP1A1/2 and CYP2C19 in pooled HLM (human livers). Carbosulfan activation is predominantly catalyzed in humans by CYP3A4. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450Research Areas >>Infection |
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| References | [1]. Abass K, et al. Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved. Chem Biol Interact. 2010 May 14;185(3):163-173. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 462.5±55.0 °C at 760 mmHg |
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| Molecular Formula | C20H32N2O3S |
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| Molecular Weight | 380.545 |
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| Flash Point | 233.5±31.5 °C |
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| Exact Mass | 380.213348 |
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| PSA | 67.31000 |
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| LogP | 6.05 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.540 |
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| InChIKey | JLQUFIHWVLZVTJ-UHFFFAOYSA-N |
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| SMILES | CCCCN(CCCC)SN(C)C(=O)Oc1cccc2c1OC(C)(C)C2 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- EZ3815000
- CHEMICAL NAME :
- Carbamic acid, ((dibutylamino)thio)methyl-, 2,2-dimethyl-2,3-dihydro-7-benzofuranyl ester
- CAS REGISTRY NUMBER :
- 55285-14-8
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C20-H32-N2-O3-S
- MOLECULAR WEIGHT :
- 380.60
- WISWESSER LINE NOTATION :
- T56 BOT&J C1 C1 HOVN1&SN4&4
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 51 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1530 mg/m3/1H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 74 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- 82 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - duck
- DOSE/DURATION :
- 8100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 26 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 29600 ug/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 345,111,1995
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Safety Information
| Symbol |
GHS06, GHS09 |
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| Signal Word | Danger |
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| Hazard Statements | H301-H317-H330-H410 |
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| Precautionary Statements | P260-P273-P280-P284-P301 + P310-P310 |
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| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
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| Hazard Codes | T:Toxic |
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| Risk Phrases | R23/25;R43;R50/53 |
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| Safety Phrases | S24-S37-S38-S45-S60-S61 |
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| RIDADR | UN 2810 |
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| RTECS | EZ3815000 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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Articles1
More Articles
| Nature of N-S bond cleavage of 2,3-dihydro-2,2-dimethyl-7-benzofuranyl (di-n-butylaminosulfenyl) (methyl)carbamate. J. Environ. Sci. Health B 15(1) , 1-23, (1980) The cleavage of the N-S bond in 2,3-dihydro-2,2-dimethyl-7-benzofuranyl (di-n-butylaminosulfenyl) (methyl)carbamate was examined in different buffer solutions (hydrolysis), in buffer solution containi... | |
Synonyms
| 2,3-dihydro-2,2-dimethyl-7-benzofuranyl N-[(dibutylamino)thio]-N-methylcarbamate |
| marshall |
| Carbosulfan |
| Sheriff |
| MARSHAL |
| 2,3-dihydro-2,2-dimethylbenzofuran-7-yl (dibutylaminothio)methylcarbamate |
| AMITAGE |
| DBSC |
| EINECS 259-565-9 |
| MFCD00143930 |
| 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl [(dibutylamino)sulfanyl]methylcarbamate |
| Posse |
| Versal |
| BRIGHT |
