CAS 68767-14-6|Loxoprofen
| Common Name | Loxoprofen | ||
|---|---|---|---|
| CAS Number | 68767-14-6 | Molecular Weight | 246.302 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 417.9±20.0 °C at 760 mmHg |
| Molecular Formula | C15H18O3 | Melting Point | 108.5 - 111ºC |
| MSDS | ChineseUSA | Flash Point | 220.7±18.3 °C |
Names
| Name | loxoprofen |
|---|---|
| Synonym | More Synonyms |
Loxoprofen BiologicalActivity
| Description | Loxoprofen is a non-steroidal anti-inflammatory drug.Target: COXLoxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. Loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/Immunology |
| Target | COX-1:6.5 μM (IC50, in human whole blood) COX-2:13.5 μM (IC50, in human whole blood) |
| References | [1]. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1201-3. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 417.9±20.0 °C at 760 mmHg |
| Melting Point | 108.5 - 111ºC |
| Molecular Formula | C15H18O3 |
| Molecular Weight | 246.302 |
| Flash Point | 220.7±18.3 °C |
| Exact Mass | 246.125595 |
| PSA | 54.37000 |
| LogP | 1.87 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.568 |
| InChIKey | YMBXTVYHTMGZDW-UHFFFAOYSA-N |
| SMILES | CC(C(=O)O)c1ccc(CC2CCCC2=O)cc1 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2918300090 |
Customs
| HS Code | 2918300090 |
|---|---|
| Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
Articles33
More Articles| Determination of nonsteroidal anti-inflammatory drugs in human tear and plasma samples using ultra-fast liquid chromatography-tandem mass spectrometry. Jpn. J. Ophthalmol. 59 , 364-71, (2015) To evaluate a new rapid and sensitive method for analyzing human tears and plasma for nonsteroidal anti-inflammatory drugs (NSAIDs) and investigate the influence of the transfer of NSAIDs in an ocular... | |
| Risk of peptic ulcer bleeding associated with Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, low-dose aspirin, and antihypertensive drugs: a case-control study. J. Gastroenterol. Hepatol. 30(2) , 292-8, (2015) The associations between antithrombotic or antihypertensive drugs and peptic ulcer bleeding (PUB) remain unknown, particularly in Asia, where Helicobacter pylori infection is prevalent. This study aim... | |
| Effect of X-ray exposure on the pharmaceutical quality of drug tablets using X-ray inspection equipment. Drug Dev. Ind. Pharm. 41 , 953-8, (2015) X-ray inspection equipment is widely used to detect missing materials and defective goods in opaque containers. Its application has been expanded to the pharmaceutical industry to detect the presence ... |
Synonyms
| IOXOPROFEN |
| MFCD00864331 |
| KOLOXO |
| Benzeneacetic acid, α-methyl-4-[(2-oxocyclopentyl)methyl]- |
| 2-{4-[(2-Oxocyclopentyl)methyl]phenyl}propanoic acid |
| Loxoprofen |
