CAS 191217-81-9|Pramipexole dihydrochloride hydrate
| Common Name | Pramipexole dihydrochloride hydrate | ||
|---|---|---|---|
| CAS Number | 191217-81-9 | Molecular Weight | 302.264 |
| Density | / | Boiling Point | 378ºC at 760 mmHg |
| Molecular Formula | C10H21Cl2N3OS | Melting Point | 290 °C(dec.) |
| MSDS | / | Flash Point | 182.4ºC |
Names
| Name | pramipexole hydrochloride |
|---|---|
| Synonym | More Synonyms |
Pramipexole dihydrochloride hydrate BiologicalActivity
| Description | Pramipexole dihydrochloride hydrate is a selective dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride hydrate can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS). Pramipexole dihydrochloride hydrate can cross the blood-brain barrier (BBB)[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
| Target | D2 Receptor:3.9 nM (Ki) D3 Receptor:0.5 nM (Ki) D4 Receptor:1.3 nM (Ki) D2-type receptors:2.2 nM (Ki) |
| In Vitro | Pramipexole dihydrochloride hydrate (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size[3]. Pramipexole dihydrochloride hydrate attenuates levodopa-induced toxicity in mesencephalic cultures, suggests that pramipexole may be cytoprotective to dopamine neurons in tissue culture[4]. |
| In Vivo | Pramipexole dihydrochloride hydrate (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals[5]. Pramipexole dihydrochloride hydrate improves neurological recovery[5]. Pramipexole dihydrochloride hydrate prevents ischemic cell death via mitochondrial pathways in ischemic stroke[5]. Animal Model: Male Wistar rats weighing 250-300 g (16-18 weeks old)[5] Dosage: 0.25 mg/kg, 1 mg/kg Administration: Intraperitoneal injection, at 1 hour, 6 hours, 12 hours, 18 hours post-occlusion Result: Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals. |
| References | [1]. Kvernmo, T., et al. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther, 2006. 28(8): p. 1065-78. [2]. Takashi Okura, et al. Blood-brain barrier transport of pramipexole, a dopamine D2 agonist. Life Sci. 2007 Apr 3;80(17):1564-71. [3]. Ginetta Collo, et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018; 2018: 4196961. [4]. P M Carvey, et al. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neural Transm (Vienna). 1997;104(2-3):209-28. [5]. Syed Suhail Andrabi, et al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 1; 12(8): dmm033860. |
Chemical & Physical Properties
| Boiling Point | 378ºC at 760 mmHg |
|---|---|
| Melting Point | 290 °C(dec.) |
| Molecular Formula | C10H21Cl2N3OS |
| Molecular Weight | 302.264 |
| Flash Point | 182.4ºC |
| Exact Mass | 301.078247 |
| PSA | 88.41000 |
| LogP | 4.09400 |
| Vapour Pressure | 9.93E-11mmHg at 25°C |
| InChIKey | APVQOOKHDZVJEX-QTPLPEIMSA-N |
| SMILES | CCCNC1CCc2nc(N)sc2C1.Cl.Cl.O |
| Storage condition | 2-8°C |
| Water Solubility | Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
Safety Information
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | DL3375000 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Synonyms
| 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N-propyl-, (6S)-, hydrochloride, hydrate (1:2:1) |
| (6S)-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride hydrate |
| (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole Dihydrochloride Monohydrate |
| Pramipexole dihydrochloride |
| Pramipexole dihydroch |
| pramipexole 2hcl monohydrate |
| (S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride PPX dihydrochloride |
| Pramipexole Dihydrochloride Monohydrate |
| Pramipexole |
