CAS 119-47-1|2,2'-Methylenebis(6-tert-butyl-4-methylphenol)

Introduction：Basic information about CAS 119-47-1|2,2'-Methylenebis(6-tert-butyl-4-methylphenol), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Articles8
7. Synonyms

Common Name	2,2'-Methylenebis(6-tert-butyl-4-methylphenol)
CAS Number	119-47-1	Molecular Weight	340.499
Density	1.0±0.1 g/cm3	Boiling Point	428.6±40.0 °C at 760 mmHg
Molecular Formula	C₂₃H₃₂O₂	Melting Point	123-127 °C(lit.)
MSDS	ChineseUSA	Flash Point	181.2±21.9 °C
Symbol	GHS08	Signal Word	Warning

Names

Name	2,2-Methylenebis(6-Tert-Butyl-4-Methylphenol)
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	428.6±40.0 °C at 760 mmHg
Melting Point	123-127 °C(lit.)
Molecular Formula	C₂₃H₃₂O₂
Molecular Weight	340.499
Flash Point	181.2±21.9 °C
Exact Mass	340.240234
PSA	40.46000
LogP	7.03
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.551
InChIKey	KGRVJHAUYBGFFP-UHFFFAOYSA-N
SMILES	Cc1cc(Cc2cc(C)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PA3500000

CHEMICAL NAME :: Methane, 2,2'-bis(6-t-butyl-p-cresyl)-

CAS REGISTRY NUMBER :: 119-47-1

BEILSTEIN REFERENCE NO. :: 2062676

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C23-H32-O2

MOLECULAR WEIGHT :: 340.55

WISWESSER LINE NOTATION :: 1X1&1&R BQ C3R BQ CX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,240,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(8),28,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1623 mg/kg/1W-C

TOXIC EFFECTS :: Liver - other changes Blood - changes in other cell count (unspecified) Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,77,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25200 mg/kg/12W-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23096 mg/kg/78W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82995 No. of Facilities: 275 (estimated) No. of Industries: 6 No. of Occupations: 23 No. of Employees: 5131 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82995 No. of Facilities: 6941 (estimated) No. of Industries: 70 No. of Occupations: 72 No. of Employees: 150745 (estimated) No. of Female Employees: 36237 (estimated)

Safety Information

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H361f-H413
Precautionary Statements	P281
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	PA3500000
HS Code	29072900

Customs

HS Code	29072900

Articles8

Bis(2-hydroxy-3-tert-butyl-5-methyl-phenyl)-methane (bis-phenol) is a potent and selective inhibitor of the secretory pathway Ca²⁺ ATPase (SPCA1).

Biochem. Biophys. Res. Commun. 424(3) , 616-9, (2012)

The secretory pathway Ca(2+) ATPase (SPCA) provides the Golgi apparatus with a Ca(2+) supply essential for Ca(2+)-dependent enzymes involved in the post-translational modification of proteins in trans...

Effects of four bisphenolic antioxidants on lipid contents of rat liver.

Toxicol. Lett. 8(1-2) , 77-86, (1981)

Hepatic lipids were studied in Sprague-Dawley male rats given, 2,2'-methylenebis(4-ethyl-6-tert-butylphenol), 2,2'-methylenebis(4-methyl-6-tert-butylphenol), 4,4'-butylidenebis(3-methyl-6-tert-butylph...

Inhibition of the sarcoplasmic and endoplasmic calcium pump by bis(2-hydroxy-3-tert-butyl-5-methyl)methane, (bis-phenol).

Biochem. Soc. Trans. 21(2) , 106S, (1993)

Synonyms

MFCD00043641

2-tert-Butyl-6-(2-hydroxy-3-tert-butyl-5-methyl-benzyl)-4-methyl-phenol

Cyanox 2246

2,2'-Methylenebis[4-methyl-6-(2-methyl-2-propanyl)phenol]

3,3'-Di-tert-butyl-2,2'-dihydroxy-5,5'-dimethyldiphenylmethane

2,2'-Methylenebis(6-tert-butyl-p-cresol)

Phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl-

EINECS 204-327-1

p-Cresol, 2,2'-methylenebis[6-tert-butyl-

2,2'-Methylene-bis-(4-methyl-6-tert-butyl-phenol)

6,6'-Methylenebis(2-(tert-butyl)-4-methylphenol)

2,2'-methylenebis(6-tert-butyl-4-methylphenol)

Bis(3-tert-butyl-2-hydroxy-5-methylphenyl)methane

bis-[2-hydroxy-5-methyl-3-tert-butylphenyl]-methane

1X1&1&R BQ E1 C1R BQ E1 CX1&1&1

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