CAS 14484-47-0|Deflazacort

Introduction：Basic information about CAS 14484-47-0|Deflazacort, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Deflazacort BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles32
8. Synonyms

Common Name	Deflazacort
CAS Number	14484-47-0	Molecular Weight	441.517
Density	1.4±0.1 g/cm3	Boiling Point	595.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₁NO₆	Melting Point	255-256.5ºC
MSDS	ChineseUSA	Flash Point	313.9±30.1 °C

Names

Name	Deflazacort
Synonym	More Synonyms

Deflazacort BiologicalActivity

Description	Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.Target: Glucocorticoid ReceptorDeflazacort is an inactive prodrug which is converted rapidly to the active metabolite 21-desacetyldeflazacort. Maximum concentrations of 21-desacetyldeflazacort averaged 116 ng/ml and were observed after 1.3 h. The average area under the curve was 280 ng/ml.h, and the terminal half-life was 1.3 h. 21-Desacetyldeflazacort was cleared significantly faster than both methylprednisolone and prednisolone [1]. Two of 40 boys treated with deflazacort died at 13 and 18 years of age from cardiac failure. The treated boys were significantly shorter, did not have excessive weight gain and 22 of 40 had asymptomatic cataracts. Deflazacort has a very significant impact on health, quality of life and health care costs for boys with DMD and their families, and is associated with few side effects [2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Glucocorticoid ReceptorResearch Areas >>Inflammation/Immunology
References	[1]. Mollmann, H., et al., Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone. Pharmaceutical research, 1995. 12(7): p. 1096-1100. [2]. Biggar, W., et al., Long-term benefits of deflazacort treatment for boys with Duchenne muscular dystrophy in their second decade. Neuromuscular Disorders, 2006. 16(4): p. 249-255.

Description

Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.Target: Glucocorticoid ReceptorDeflazacort is an inactive prodrug which is converted rapidly to the active metabolite 21-desacetyldeflazacort. Maximum concentrations of 21-desacetyldeflazacort averaged 116 ng/ml and were observed after 1.3 h. The average area under the curve was 280 ng/ml.h, and the terminal half-life was 1.3 h. 21-Desacetyldeflazacort was cleared significantly faster than both methylprednisolone and prednisolone [1]. Two of 40 boys treated with deflazacort died at 13 and 18 years of age from cardiac failure. The treated boys were significantly shorter, did not have excessive weight gain and 22 of 40 had asymptomatic cataracts. Deflazacort has a very significant impact on health, quality of life and health care costs for boys with DMD and their families, and is associated with few side effects [2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Glucocorticoid ReceptorResearch Areas >>Inflammation/Immunology

References

[1]. Mollmann, H., et al., Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone. Pharmaceutical research, 1995. 12(7): p. 1096-1100.

[2]. Biggar, W., et al., Long-term benefits of deflazacort treatment for boys with Duchenne muscular dystrophy in their second decade. Neuromuscular Disorders, 2006. 16(4): p. 249-255.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	595.4±50.0 °C at 760 mmHg
Melting Point	255-256.5ºC
Molecular Formula	C₂₅H₃₁NO₆
Molecular Weight	441.517
Flash Point	313.9±30.1 °C
Exact Mass	441.215149
PSA	102.26000
LogP	2.02
Vapour Pressure	0.0±3.8 mmHg at 25°C
Index of Refraction	1.661
InChIKey	FBHSPRKOSMHSIF-GRMWVWQJSA-N
SMILES	CC(=O)OCC(=O)C12N=C(C)OC1CC1C3CCC4=CC(=O)C=CC4(C)C3C(O)CC12C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4157050

CHEMICAL NAME :: 5'-beta-H-Pregna-1,4-dieno(17,16-d)oxazole-3,20-dione , 11-beta,21-dihydroxy-2'-methyl-, 21-acetate

CAS REGISTRY NUMBER :: 14484-47-0

LAST UPDATED :: 199009

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C25-H31-N-O6

MOLECULAR WEIGHT :: 441.57

WISWESSER LINE NOTATION :: T F5 E5 B666 GN IO RV GU AHTTTT&J A1 CQ E1 FV1OV1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1543,1980

Safety Information

Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
RTECS	TU4157050
HS Code	2937290090

Customs

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles32

Health-related quality of life in children and adolescents with Duchenne muscular dystrophy.

Pediatrics 130(6) , e1559-66, (2012)

The purpose of this study was to assess health-related quality of life (QoL) in children with Duchenne muscular dystrophy (DMD), including development and field-testing of a DMD-specific module integr...

Early corticosteroid treatment in 4 Duchenne muscular dystrophy patients: 14-year follow-up.

Muscle Nerve 45(6) , 796-802, (2012)

Corticosteroid treatment is the standard of care in Duchenne muscular dystrophy (DMD), but the optimal age to initiate treatment and dosage pattern remain a matter of discussion.We performed a long-te...

Treatment of dysferlinopathy with deflazacort: a double-blind, placebo-controlled clinical trial.

Orphanet J. Rare Dis. 8 , 26, (2013)

Dysferlinopathies are autosomal recessive disorders caused by mutations in the dysferlin (DYSF) gene encoding the dysferlin protein. DYSF mutations lead to a wide range of muscular phenotypes, with th...

Synonyms

Deflazacort

2-[(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-Hydroxy-4a,6a,8-trimethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-6b-yl]-2-oxoethyl acetate

11b,21-Dihydroxy-2'-methyl-5'bH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 21-acetate

Pregna-1,4-diene-11b,21-diol-3,20-dione[17a,16a-d]-2'-methyloxazoline 21-Acetate

Calcort

DL 458-IT

(11b,16b)-21-(Acetyloxy)-11-hydroxy-2'-methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione

Dezacor

Lantadin

Cortax,Decortil,Deflanil

Deflan

2H-Naphth[2',1':4,5]indeno[1,2-d]oxazol-2-one, 6b-[2-(acetyloxy)acetyl]-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-4a,6a,8-trimethyl-, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-

Flantadin

EINECS 238-483-7

Azacort

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