Introduction：Basic information about CAS 129-43-1|1-HYDROXYANTHRAQUINONE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-HYDROXYANTHRAQUINONE |
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| CAS Number | 129-43-1 | Molecular Weight | 224.212 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 414.8±14.0 °C at 760 mmHg |
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| Molecular Formula | C14H8O3 | Melting Point | 194°C |
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| MSDS | / | Flash Point | 218.8±16.6 °C |
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Names
| Name | 1-hydroxyanthraquinone |
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| Synonym | More Synonyms |
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1-HYDROXYANTHRAQUINONE BiologicalActivity
| Description | 1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis |
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| In Vivo | 1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats[1]. Animal Model: Thirty rats[1]. Dosage: 1% HA in diet. Administration: Diet. Result: Associated with decreased weight gain which was particularly marked towards the termination of experiment. One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment. A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon. Seven animals of the group died spontaneously or were sacrificed upon becomingmoribund between 335 and 462 days. A total of 21 rats of group 1 survived until the end of experiment (mean value of totalintake of HA/rat was 76.8 g). |
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| References | [1]. H Mori, et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Carcinogenesis. 1990 May;11(5):799-802. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 414.8±14.0 °C at 760 mmHg |
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| Melting Point | 194°C |
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| Molecular Formula | C14H8O3 |
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| Molecular Weight | 224.212 |
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| Flash Point | 218.8±16.6 °C |
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| Exact Mass | 224.047348 |
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| PSA | 54.37000 |
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| LogP | 3.97 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.695 |
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| InChIKey | BTLXPCBPYBNQNR-UHFFFAOYSA-N |
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| SMILES | O=C1c2ccccc2C(=O)c2c(O)cccc21 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CB7178000
- CHEMICAL NAME :
- Anthraquinone, 1-hydroxy-
- CAS REGISTRY NUMBER :
- 129-43-1
- BEILSTEIN REFERENCE NO. :
- 1912751
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C14-H8-O3
- MOLECULAR WEIGHT :
- 224.22
- WISWESSER LINE NOTATION :
- L C666 BV IVJ DQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 288 gm/kg/68W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 147 gm/kg/42W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors
MUTATION DATA - TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 50 umol/L
- REFERENCE :
- CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- Volume(issue)/page/year: 2,457,1986
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26-S36/37/39 |
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| RTECS | CB7178000 |
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| Packaging Group | III |
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| HS Code | 2914690090 |
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Customs
| HS Code | 2914690090 |
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| Summary | 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 9,10-Anthracenedione, 1-hydroxy- |
| EINECS 204-946-7 |
| 1-HYDROXYANTHRAQUINONE |
| 1-hydroxyanthracene-9,10-dione |
| 1-Hydroxy-9,10-anthraquinone |
| HYDROXY-9,10-ANTHRACENEDIONE |
| MFCD00058946 |
| 1-Hydroxy anthraquinone |
