CAS 866460-33-5|Setipiprant

Introduction：Basic information about CAS 866460-33-5|Setipiprant, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Setipiprant BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Setipiprant
CAS Number	866460-33-5	Molecular Weight	402.418
Density	1.4±0.1 g/cm3	Boiling Point	690.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₄H₁₉FN₂O₃	Melting Point	/
MSDS	/	Flash Point	371.4±31.5 °C

Names

Name	2-[8-fluoro-2-(naphthalene-1-carbonyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl]acetic acid
Synonym	More Synonyms

Setipiprant BiologicalActivity

Description	Setipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein-coupled receptor for PGD2.IC50 value: 6.0 nMTarget: PGD2in vitro: Setipiprant is an orally available, selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T helper [Th]-2 cells) antagonist. CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells. Thus, antagonism of CRTH2 receptors is considered to be a promising therapeutic target for various allergic diseases and asthma.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorResearch Areas >>Inflammation/Immunology

Description

Setipiprant is an orally available, selective CRTH2 antagonist. CRTH2 is a G protein-coupled receptor for PGD2.IC50 value: 6.0 nMTarget: PGD2in vitro: Setipiprant is an orally available, selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T helper [Th]-2 cells) antagonist. CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells. Thus, antagonism of CRTH2 receptors is considered to be a promising therapeutic target for various allergic diseases and asthma.

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorResearch Areas >>Inflammation/Immunology

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	690.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₄H₁₉FN₂O₃
Molecular Weight	402.418
Flash Point	371.4±31.5 °C
Exact Mass	402.137970
PSA	62.54000
LogP	3.39
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.682
InChIKey	IHAXLPDVOWLUOS-UHFFFAOYSA-N
SMILES	O=C(O)Cn1c2c(c3cc(F)ccc31)CN(C(=O)c1cccc3ccccc13)CC2
Storage condition	-20℃

Synonyms

[8-Fluoro-2-(1-naphthoyl)-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl]acetic acid

Setipiprant

5H-Pyrido[4,3-b]indole-5-acetic acid, 8-fluoro-1,2,3,4-tetrahydro-2-(1-naphthalenylcarbonyl)-

UNII-BHF20LA2GM

2-(2-(1-Naphthoyl)-8-fluoro-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)acetic acid

ACT-129968

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