Introduction：Basic information about CAS 51025-85-5|HBK, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | HBK |
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| CAS Number | 51025-85-5 | Molecular Weight | 552.619 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 904.0±65.0 °C at 760 mmHg |
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| Molecular Formula | C22H44N6O10 | Melting Point | / |
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| MSDS | / | Flash Point | 500.5±34.3 °C |
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Names
| Name | arbekacin |
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| Synonym | More Synonyms |
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HBK BiologicalActivity
| Description | Arbekacin, an aminoglycoside antibiotic, exhibits broad antimicrobial activities against not only Gram-positive bacteria but also Gram-negative bacteria[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Arbekaci 有效抑制鲍氏不动杆菌 (MIC50=2 μg/mL) 和来自 PHP 的肠杆菌科 (MIC50=0.25-2 μg/mL; MIC90=1-8 μg/mL)[1]。 Arbekacin 也抑制全球范围内特征明确的耐多药革兰氏阴性和 MRSA 菌株[1]。 |
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| References | [1]. Matsumoto T. Arbekacin: another novel agent for treating infections due to methicillin-resistant Staphylococcus aureus and multidrug-resistant Gram-negative pathogens. Clin Pharmacol. 2014 Sep 26;6:139-48. [2]. Sader HS, et al. Arbekacin activity against contemporary clinical bacteria isolated from patients hospitalized with pneumonia. Antimicrob Agents Chemother. 2015;59(6):3263-70. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 904.0±65.0 °C at 760 mmHg |
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| Molecular Formula | C22H44N6O10 |
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| Molecular Weight | 552.619 |
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| Flash Point | 500.5±34.3 °C |
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| Exact Mass | 552.311890 |
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| PSA | 297.27000 |
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| LogP | -4.00 |
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| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
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| Index of Refraction | 1.635 |
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| InChIKey | MKKYBZZTJQGVCD-HLPHASHQSA-N |
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| SMILES | NCCC(O)C(=O)NC1CC(N)C(OC2OC(CN)CCC2N)C(O)C1OC1OC(CO)C(O)C(N)C1O |
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Synonyms
| AHB-DKB |
| HBK |
| HABA-DKB |
| MFCD00864919 |
| 4-Amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide |
| (S)-O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1®6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-erythrohexopyranosyl-(1®4)]-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine |
| 3-AMINO-2-METHOXY-4-PICOLINE |
| 1-N-[(S)-4-Amino-2-hydroxybutyryl]-3',4'-dideoxykanamycin B |
| Haberacin |
| Butanamide, 4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)oxy]-3-hydroxycyclohexyl]-2-hydroxy- |
| Arbekacin |
| 1-N-[(S)-4-Amino-2-hydroxybutyryl]dibekacin |
