CAS 9076-44-2|chymostatin
| Common Name | chymostatin | ||
|---|---|---|---|
| CAS Number | 9076-44-2 | Molecular Weight | 607.701 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
| Molecular Formula | C31H41N7O6 | Melting Point | 276-278℃ |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | N-[-Nα-carbonyl-capreomycidine-Val-Phe-al]-Phe |
|---|---|
| Synonym | More Synonyms |
chymostatin BiologicalActivity
| Description | Chymostatin is a potent cathepsin G inhibitor. Chymostatin inhibits fungal growth when combined with other pepsin inhibitors. Chymostatin can be used for acute lung injury and pancreatitis research[1]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>Cathepsin |
| References | [1]. Chen Yang, et al. Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice. Inflammation |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Melting Point | 276-278℃ |
| Molecular Formula | C31H41N7O6 |
| Molecular Weight | 607.701 |
| Exact Mass | 607.311829 |
| PSA | 201.61000 |
| LogP | 4.00 |
| Index of Refraction | 1.640 |
| InChIKey | MRXDGVXSWIXTQL-ZFXZZAOISA-N |
| SMILES | CC(C)CC(NC(=O)C(NC(=O)NC(Cc1ccccc1)C(=O)O)C1CCN=C(N)N1)C(=O)NC(C=O)Cc1ccccc1 |
| Storage condition | −20°C |
| Water Solubility | DMSO: 10 mM Stock solutions stable for months at −20 °C. |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 22-24/25-36-26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | GC3047700 |
Articles39
More Articles| Enabling Low Cost Biopharmaceuticals: A Systematic Approach to Delete Proteases from a Well-Known Protein Production Host Trichoderma reesei. PLoS ONE 10 , e0134723, (2015) The filamentous fungus Trichoderma reesei has tremendous capability to secrete proteins. Therefore, it would be an excellent host for producing high levels of therapeutic proteins at low cost. Develop... | |
| Estrogen inhibits mast cell chymase release to prevent pressure overload-induced adverse cardiac remodeling. Hypertension 65(2) , 328-34, (2015) Estrogen regulation of myocardial chymase and chymase effects on cardiac remodeling are unknown. To test the hypothesis that estrogen prevents pressure overload-induced adverse cardiac remodeling by i... | |
| Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism. Am. J. Physiol. Heart Circ. Physiol. 305(5) , H644-50, (2013) Angiotensin-(1-12) [ANG-(1-12)], a new member of the renin-angiotensin system, is recognized as a renin independent precursor for ANG II. However, the processing of ANG-(1-12) in the circulation in vi... |
Synonyms
| N-{[(1S)-1-[(4S)-2-Amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-2-{[(2S)-4-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenyl-2-propanyl]amino}-2-pentanyl]amino}-2-oxoethyl]carbamoyl}-L-phenylalanine |
| MFCD00071059 |
| CHYMOSTATIN (MICROBIAL PRODUCT) |
| Chymostatin |
| CHYMOSTATIN, 5 MG |
| L-Phenylalanine, N-[[[(1S)-2-[[(1S)-1-[[[(1S)-1-formyl-2-phenylethyl]amino]carbonyl]-3-methylbutyl]amino]-1-[(4S)-hexahydro-2-imino-4-pyrimidinyl]-2-oxoethyl]amino]carbonyl]- |
| CHYMOSTATIN (25 MG ) |
| CHYMOSTATIN (ACTINOMYCETES) |
