CAS 5573-16-0|Saikogenin D

Introduction：Basic information about CAS 5573-16-0|Saikogenin D, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Saikogenin D BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Saikogenin D
CAS Number	5573-16-0	Molecular Weight	472.700
Density	1.2±0.1 g/cm3	Boiling Point	607.4±55.0 °C at 760 mmHg
Molecular Formula	C₃₀H₄₈O₄	Melting Point	261-266 °C
MSDS	/	Flash Point	252.4±26.1 °C

Names

Name	3β,16α,23,28-Tetrahydroxyoleana-11(12),13(18)-diene
Synonym	More Synonyms

Saikogenin D BiologicalActivity

Description	Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel
In Vitro	Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells[1]. Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells[1].
References	[1]. Toriniwa Y, et al. Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis.J Pharm Pharmacol. 2006 Jun;58(6):859-66. [2]. Kodama Y, et al. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells.Planta Med. 2003 Aug;69(8):765-7.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	607.4±55.0 °C at 760 mmHg
Melting Point	261-266 °C
Molecular Formula	C₃₀H₄₈O₄
Molecular Weight	472.700
Flash Point	252.4±26.1 °C
Exact Mass	472.355255
PSA	80.92000
LogP	5.38
Vapour Pressure	0.0±3.9 mmHg at 25°C
Index of Refraction	1.586
InChIKey	QGNVMEXLLPGQEV-IULQVHCXSA-N
SMILES	CC1(C)CCC2(CO)C(=C3C=CC4C5(C)CCC(O)C(C)(CO)C5CCC4(C)C3(C)CC2O)C1

Synonyms

(3β,16α)-Oleana-11,13(18)-diene-3,16,23,28-tetrol

Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,16α)-

Saikogenin D

Recommended......