Introduction：Basic information about CAS 1493764-08-1|UNC 2881, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | UNC 2881 |
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| CAS Number | 1493764-08-1 | Molecular Weight | 463.575 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C25H33N7O2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | 5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]- |
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| Synonym | More Synonyms |
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UNC 2881 BiologicalActivity
| Description | UNC2881 is a potent and specific Mer kinase inhibitor; inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. IC50 value: 22 nM [1]Target: Mer kinase inhibitorTreatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis. |
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| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>TAM ReceptorResearch Areas >>Cardiovascular Disease |
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| References | [1]. Zhang W, et al. Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J Med Chem. 2013 Dec 12;56(23):9693-700. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C25H33N7O2 |
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| Molecular Weight | 463.575 |
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| Exact Mass | 463.269562 |
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| PSA | 116.99000 |
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| LogP | 3.03 |
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| Index of Refraction | 1.666 |
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| InChIKey | NPVXOWLPOFYACO-UHFFFAOYSA-N |
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| SMILES | CCCCNc1ncc(C(=O)NCc2ccc(-n3ccnc3)cc2)c(NC2CCC(O)CC2)n1 |
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| Storage condition | -20℃ |
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| Water Solubility | Insuluble (1.7E-3 g/L) (25 ºC) |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302 |
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| Precautionary Statements | P301 + P312 + P330 |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| 5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]- |
| 2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[4-(1H-imidazol-1-yl)benzyl]-5-pyrimidinecarboxamide |
| UNC2881 |
