CAS 1594092-37-1|AZ 191

Introduction：Basic information about CAS 1594092-37-1|AZ 191, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. AZ 191 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	AZ 191
CAS Number	1594092-37-1	Molecular Weight	429.51700
Density	/	Boiling Point	/
Molecular Formula	C₂₄H₂₇N₇O	Melting Point	/
MSDS	USA	Flash Point	/

Names

Name	2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-
Synonym	More Synonyms

AZ 191 BiologicalActivity

Description	AZ191 is a potent small molecule inhibitor that selectively inhibits DYRK1B with IC50 of 17 nM; selective for DYRK1B over both DYRK1A and DYRK2.IC50 value: 17 nM [1]Target: DYRK1B inhibitorin vitro: Using in vitro kinase assays, phospho-specific immunoblot analysis and MS in conjunction with AZ191 we now show that DYRK1B phosphorylates CCND1 at Thr(286), not Thr(288), in vitro and in cells. In HEK (human embryonic kidney)-293 and PANC-1 cells (which exhibit DYRK1B amplification) DYRK1B drives Thr(286) phosphorylation and proteasome-dependent turnover of CCND1 and this is abolished by AZ191 or DYRK1B RNAi, but not by GSK3β inhibitors or GSK3β RNAi.
Related Catalog	Signaling Pathways >>Protein Tyrosine Kinase/RTK >>DYRKResearch Areas >>Cancer
References	[1]. Ashford AL, et al. A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288). Biochem J. 2014 Jan 1;457(1):43-56.

Chemical & Physical Properties

Molecular Formula	C₂₄H₂₇N₇O
Molecular Weight	429.51700
Exact Mass	429.22800
PSA	71.34000
LogP	3.61020
InChIKey	ZYVXTMKTGDARKR-UHFFFAOYSA-N
SMILES	COc1cc(N2CCN(C)CC2)ccc1Nc1nccc(-c2cn(C)c3cnccc23)n1
Storage condition	-20℃

Safety Information

RIDADR	NONH for all modes of transport

Synonyms

[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine

AZ191

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