Introduction：Basic information about CAS 957485-64-2|FPH2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | FPH2 |
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| CAS Number | 957485-64-2 | Molecular Weight | 353.82700 |
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| Density | 1.45±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C14H16ClN5O2S | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | 1H-Pyrazole-3-carboxamide, 4-[[[(5-chloro-2-methoxyphenyl)amino]thioxomethyl]amino]-1-ethyl- |
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| Synonym | More Synonyms |
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FPH2 BiologicalActivity
| Description | FPH2 induces of functional proliferation of primary human hepatocytes and may lead to the development of new therapeutics for liver diseases. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>CancerResearch Areas >>Metabolic Disease |
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| In Vitro | FPH2 induces functional proliferation of hepatocytes in vitro, and thus may be useful for expanding mature human primary hepatocytes. FPH1 and FPH2 can increase in hepatocyte nuclei count and/or elevate the number of nuclei undergoing mitosis during primary screening, and these effects on hepatocytes are concentration dependent. Cells treated with FPH1 and FPH2 also maintain their liver-specific functions. Over 7 days, FPH2 induces hepatocyte doublings at a rate that is consistent with reported liver regeneration kinetics in vivo[1]. |
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| References | [1]. Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug;9(8):514-20. |
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Chemical & Physical Properties
| Density | 1.45±0.1 g/cm3 |
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| Molecular Formula | C14H16ClN5O2S |
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| Molecular Weight | 353.82700 |
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| Exact Mass | 353.07100 |
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| PSA | 126.29000 |
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| LogP | 3.31910 |
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| InChIKey | PCHRYHSDDPPZBV-UHFFFAOYSA-N |
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| SMILES | CCn1cc(NC(=S)Nc2cc(Cl)ccc2OC)c(C(N)=O)n1 |
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| Storage condition | -20℃ |
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| Water Solubility | Practically insoluble (0.046 g/L) (25 ºC) |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| FPH2 |
| 4-[[[(5-Chloro-2-methoxyphenyl)amino]thioxomethyl]amino]-1-ethyl-1H-pyrazole-3-carboxamide |
| BRD-9424 |
