CAS 199327-61-2|Gefitinib impurity 5

Introduction：Basic information about CAS 199327-61-2|Gefitinib impurity 5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameGefitinib impurity 5
CAS Number199327-61-2Molecular Weight319.356
Density1.3±0.1 g/cm3Boiling Point564.4±50.0 °C at 760 mmHg
Molecular FormulaC16H21N3O4Melting Point/
MSDS/Flash Point295.2±30.1 °C

Names

Name7-methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one
SynonymMore Synonyms

Gefitinib impurity 5 BiologicalActivity

DescriptionGefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
Related CatalogResearch Areas >>OthersSignaling Pathways >>Others >>Others
References

[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

Chemical & Physical Properties

Density1.3±0.1 g/cm3
Boiling Point564.4±50.0 °C at 760 mmHg
Molecular FormulaC16H21N3O4
Molecular Weight319.356
Flash Point295.2±30.1 °C
Exact Mass319.153198
PSA76.68000
LogP0.29
Vapour Pressure0.0±1.5 mmHg at 25°C
Index of Refraction1.611
InChIKeyWFUBWLXSYCFZEH-UHFFFAOYSA-N
SMILESCOc1cc2nc[nH]c(=O)c2cc1OCCCN1CCOCC1
Storage condition2~8℃

Safety Information

Hazard CodesXi
HS Code2934999090

Customs

HS Code2934999090
Summary2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

4(3H)-Quinazolinone, 7-methoxy-6-[3-(4-morpholinyl)propoxy]-
7-Methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4(3H)-one
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(1H)-quinazolinone
Gefitinib Impurity 17
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