CAS 1421372-66-8|Mutated EGFR-IN-1
Introduction：Basic information about CAS 1421372-66-8|Mutated EGFR-IN-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mutated EGFR-IN-1 | ||
|---|---|---|---|
| CAS Number | 1421372-66-8 | Molecular Weight | 445.560 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 676.5±65.0 °C at 760 mmHg |
| Molecular Formula | C25H31N7O | Melting Point | / |
| MSDS | / | Flash Point | 363.0±34.3 °C |
Names
| Name | N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine |
|---|---|
| Synonym | More Synonyms |
Mutated EGFR-IN-1 BiologicalActivity
| Description | Mutated EGFR-IN-1 is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.IC50 value:Target: Mutated EGFR inhibitorMore information can be found in Patent WO 2013014448 A1.2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer. |
|---|---|
| Related Catalog | Research Areas >>Cancer |
| Target | EGFRL858R EGFRExon 19 deletion/T790M EGFRT790M |
| References | [1]. Patent WO 2013014448 A1. 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 676.5±65.0 °C at 760 mmHg |
| Molecular Formula | C25H31N7O |
| Molecular Weight | 445.560 |
| Flash Point | 363.0±34.3 °C |
| Exact Mass | 445.259003 |
| PSA | 84.47000 |
| LogP | 2.17 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.635 |
| InChIKey | HTNTZPBKKCORTP-UHFFFAOYSA-N |
| SMILES | COc1cc(N(C)CCN(C)C)c(N)cc1Nc1nccc(-c2cn(C)c3ccccc23)n1 |
| Storage condition | 2-8℃ |
Synonyms
| Mutated EGFR-IN-1 |
| AZD9291 intermediate 3 |
| 1,2,4-Benzenetriamine, N-[2-(dimethylamino)ethyl]-5-methoxy-N-methyl-N-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]- |
| N-[2-(Dimethylamino)ethyl]-5-methoxy-N-methyl-N-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine |
| N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N 1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]benzene-1,2,4-triamine |
