Introduction：Basic information about CAS 5116-24-5|5-Hydroxymethyl-2'-deoxyuridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5-Hydroxymethyl-2'-deoxyuridine |
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| CAS Number | 5116-24-5 | Molecular Weight | 258.228 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 401.48°C (rough estimate) |
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| Molecular Formula | C10H14N2O6 | Melting Point | 176-179 °C |
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| MSDS | / | Flash Point | / |
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Names
| Name | 5-hydroxymethyl-2'-deoxyuridine |
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| Synonym | More Synonyms |
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5-Hydroxymethyl-2'-deoxyuridine BiologicalActivity
| Description | 5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia[1][2][3]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Anti-infection >>HSVResearch Areas >>Infection |
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| In Vitro | 5-Hydroxymethyl-2'-deoxyuridine (0-10 μM) inhibits the replication of Sarcoma 180 cells and Ehrlich ascites carcinoma cells with ED50 values of 8.5 and 4 μM, respectively[1]. 5-Hydroxymethyl-2'-deoxyuridine inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase with a Ki value of 3.5 μM[1]. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM[2]. 5-Hydroxymethyl-2'-deoxyuridine (10-100 μM) shows dose-dependent toxicity against a human acute promyelocytic leukemia cell line[2]. |
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| In Vivo | 5-Hydroxymethyl-2'-deoxyuridine (0, 5 and 50 mg/kg; i.p.; once) increases the survival of DBA/2 mice carrying L1210 leukemia[3]. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 401.48°C (rough estimate) |
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| Melting Point | 176-179 °C |
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| Molecular Formula | C10H14N2O6 |
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| Molecular Weight | 258.228 |
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| Exact Mass | 258.085175 |
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| PSA | 124.78000 |
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| LogP | -1.49 |
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| Index of Refraction | 1.610 |
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| InChIKey | IPAVKOYJGUMINP-XLPZGREQSA-N |
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| SMILES | O=c1[nH]c(=O)n(C2CC(O)C(CO)O2)cc1CO |
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| Storage condition | −20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- YU7600000
- CHEMICAL NAME :
- Uridine, 2'-deoxy-5-(hydroxymethyl)-
- CAS REGISTRY NUMBER :
- 5116-24-5
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C10-H14-N2-O6
- MOLECULAR WEIGHT :
- 258.26
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 gm/kg/15D-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes Related to Chronic Data - death
MUTATION DATA - TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 4 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 373,125,1997
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Safety Information
| Risk Phrases | 24/25 |
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| Safety Phrases | 24/25 |
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| WGK Germany | 3 |
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| RTECS | YU7600000 |
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| HS Code | 2934999090 |
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Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-(2-Deoxypentofuranosyl)-5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione |
| 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxypentofuranosyl)-5-(hydroxymethyl)- |
| 5-HMdU HMdUdr |
| 1-(2-deoxypentofuranosyl)-5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione |
| 5-HYDROXYMETHYL-2'-DEOXYURIDINE |
