Introduction：Basic information about CAS 125-46-2|(±)-Usnic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (±)-Usnic acid |
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| CAS Number | 125-46-2 | Molecular Weight | 344.315 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 594.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C18H16O7 | Melting Point | 200°C |
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| MSDS | ChineseUSA | Flash Point | 219.1±23.6 °C |
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Names
| Name | usnic acid |
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| Synonym | More Synonyms |
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(±)-Usnic acid BiologicalActivity
| Description | Usnic acid, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid has excellent anticancer and antimicrobial properties. Usnic acid significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| References | [1]. Kim KJ, et al. Effect of Usnic Acid on Osteoclastogenic Activity. J Clin Med. 2018 Oct 12;7(10). pii: E345. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 594.8±50.0 °C at 760 mmHg |
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| Melting Point | 200°C |
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| Molecular Formula | C18H16O7 |
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| Molecular Weight | 344.315 |
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| Flash Point | 219.1±23.6 °C |
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| Exact Mass | 344.089600 |
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| PSA | 117.97000 |
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| LogP | 2.68 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.643 |
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| InChIKey | CUCUKLJLRRAKFN-UHFFFAOYSA-N |
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| SMILES | CC(=O)c1c(O)c(C)c(O)c2c1OC1=CC(=O)C(C(C)=O)C(=O)C12C |
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| Storage condition | 2-8C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- HP5270000
- CHEMICAL NAME :
- 1,3(2H,9bH)-dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-
- CAS REGISTRY NUMBER :
- 125-46-2
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C18-H16-O7
- MOLECULAR WEIGHT :
- 344.34
- WISWESSER LINE NOTATION :
- T B656 CV EV HO FU BHT&&J B1 DV1 JV1 KQ L1 MQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Mammal - species unspecified Cells - not otherwise specified
- DOSE/DURATION :
- 3750 ug/L
- REFERENCE :
- PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 12,280,1970
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Safety Information
| Hazard Codes | Xn:Harmful; |
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| Risk Phrases | R22 |
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| Safety Phrases | S22-S24/25 |
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| RTECS | HP5270000 |
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| HS Code | 2917399090 |
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Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Usnic acid |
| MFCD00065294 |
| EINECS 231-456-0 |
| (±)-Usnic acid |
| 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzo[b,d]furan-1,3(2H,9bH)-dione |
| 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione |
| 1,3(2H,9bH)-Dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl- |
