CAS 115956-13-3|Dolasetron (Mesylate)

Introduction：Basic information about CAS 115956-13-3|Dolasetron (Mesylate), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Dolasetron (Mesylate) BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	Dolasetron (Mesylate)
CAS Number	115956-13-3	Molecular Weight	420.48
Density	/	Boiling Point	535.1ºC at 760 mmHg
Molecular Formula	C₂₀H₂₄N₂O₆S	Melting Point	/
MSDS	ChineseUSA	Flash Point	277.4ºC

Names

Name	Dolasetron mesylate hydrate
Synonym	More Synonyms

Dolasetron (Mesylate) BiologicalActivity

Description	Dolasetron Mesylate (MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorResearch Areas >>Others
References	[1]. Faria C, et al. Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis. Am Health Drug Benefits. 2014 Jan;7(1):50-8.

Chemical & Physical Properties

Boiling Point	535.1ºC at 760 mmHg
Molecular Formula	C₂₀H₂₄N₂O₆S
Molecular Weight	420.48
Flash Point	277.4ºC
PSA	134.38000
LogP	2.97740
Vapour Pressure	1.65E-22mmHg at 25°C
InChIKey	PSGRLCOSIXJUAL-UHFFFAOYSA-N
SMILES	CS(=O)(=O)O.O=C(OC1CC2CC3CC(C1)N2CC3=O)c1c[nH]c2ccccc12
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL6015300

CHEMICAL NAME :: 1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2-alpha,6-alpha,8-alpha,9a-beta)-, monomethanesulfonate, monohydrate

CAS REGISTRY NUMBER :: 115956-13-3

LAST UPDATED :: 199801

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H20-N2-O3.C-H4-O3-S.H2-O

MOLECULAR WEIGHT :: 438.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2400 ug/kg

TOXIC EFFECTS :: Behavioral - headache Gastrointestinal - decreased motility or constipation Gastrointestinal - other changes

REFERENCE :: BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2400 ug/kg/10M-C

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - headache

REFERENCE :: BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 545 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993

Safety Information

Risk Phrases	R20/21/22

Synonyms

(1r,3R,5r,7S)-10-Oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate methanesulfonate hydrate (1:1:1)

MFCD01718979

Dolasetron mesylate

(3R,5r,7S)-10-Oxo-8-azatricyclo[5.3.1.0]undec-5-yl 1H-indole-3-carboxylate methanesulfonate hydrate (1:1:1)

1H-Indole-3-carboxylic acid, (6R,9aS)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, methanesulfonate, hydrate (1:1:1)

EINECS 214-599-3

Dolasetron (Mesylate)

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