Introduction：Basic information about CAS 127-58-2|sulfamerazine sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | sulfamerazine sodium |
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| CAS Number | 127-58-2 | Molecular Weight | 286.285 |
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| Density | / | Boiling Point | 519.1ºC at 760mmHg |
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| Molecular Formula | C11H11N4NaO2S | Melting Point | 216-219 °C |
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| MSDS | ChineseUSA | Flash Point | 267.8ºC |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | sodium,(4-aminophenyl)sulfonyl-(4-methylpyrimidin-2-yl)azanide |
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| Synonym | More Synonyms |
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sulfamerazine sodium BiologicalActivity
| Description | Sulfamerazine Sodium is a sulfonamide antibacterial.Target: AntibacterialSulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sulfamerazine is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA [1]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection |
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| References | [1]. HALL, W.H. and W.W. SPINK, Sulfamerazine: clinical evaluation in 116 cases. Journal of the American Medical Association, 1943. 123(3): p. 125-131. |
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Chemical & Physical Properties
| Boiling Point | 519.1ºC at 760mmHg |
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| Melting Point | 216-219 °C |
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| Molecular Formula | C11H11N4NaO2S |
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| Molecular Weight | 286.285 |
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| Flash Point | 267.8ºC |
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| Exact Mass | 286.050049 |
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| PSA | 97.56000 |
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| LogP | 2.68880 |
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| Vapour Pressure | 7.03E-11mmHg at 25°C |
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| InChIKey | BSFJGCCAXDCMOX-UHFFFAOYSA-N |
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| SMILES | Cc1ccnc([N-]S(=O)(=O)c2ccc(N)cc2)n1.[Na+] |
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| Storage condition | 2-8℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- WP0760000
- CHEMICAL NAME :
- Sulfanilamide, N(sup 1)-(4-methyl-2-pyrimidinyl)-, monosodium salt
- CAS REGISTRY NUMBER :
- 127-58-2
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C11-H11-N4-O2-S.Na
- MOLECULAR WEIGHT :
- 286.31
- WISWESSER LINE NOTATION :
- T6N CNJ BMSWR DZ& D1 &-NA-
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1522 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1739 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302-H315-H319-H332 |
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| Precautionary Statements | P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R20/22 |
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| Safety Phrases | S7-S24-S45 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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Synonyms
| EINECS 204-851-0 |
| Sulfamerazin natrium |
| Benzenesulfonamide, 4-amino-N-(4-methyl-2-pyrimidinyl)-, sodium salt (1:1) |
| MFCD00068332 |
| Sodium [(4-aminophenyl)sulfonyl](4-methyl-2-pyrimidinyl)azanide |
| 2-Sulfanilamido-4-methylpyrimidine sodium salt |
| Solumedine |
| UNII-JOV4UJY07O |
| Solfamerazina sodica [DCIT] |
| Sodium sulfamerazine |
| sulfamerazine sodium |
| Soluble sulfamerazine |
| Sodium sulphamerazine |
| Sodium [(4-aminophenyl)sulfonyl](4-methylpyrimidin-2-yl)azanide |
| Sulfamerazine sodium salt |
| Sulfamerazine (sodium salt) |
