CAS 54-06-8|ADRENOCHROME
| Common Name | ADRENOCHROME | ||
|---|---|---|---|
| CAS Number | 54-06-8 | Molecular Weight | 179.17300 |
| Density | 1.42g/cm3 | Boiling Point | 375.1ºC at 760 mmHg |
| Molecular Formula | C9H9NO3 | Melting Point | 115-120ºC |
| MSDS | ChineseUSA | Flash Point | 180.7ºC |
Names
| Name | 3-Hydroxy-1-methyl-5,6-indolinedione |
|---|---|
| Synonym | More Synonyms |
ADRENOCHROME BiologicalActivity
| Description | Adrenochrome (Adraxone) is an oxidation product of Epinephrine. Adrenochrome is a potent coronary constricting agent in the rat heart. Adrenochrome can be used for neurological disorder research[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| In Vitro | Adrenochrome decreases microsomal calcium binding, calcium uptake and Ca2+-stimulated Mg2+-dependent ATPase activities. The inhibitory effect of Adrenochrome on microsomal calcium uptake activity of the isolated membrane is independent of pH (6.0-8.0), calcium concentrations (10-200 μM), protein concentration (0.02-0.10 mg/mL), temperature (25-37 degrees C) and incubation time (2-30 min)[2]. |
| In Vivo | In isolated rat hearts, concentrations of Adrenochrome from 1 to 1000 ng/mL increases coronary pressure in a dose- and time-dependent manner. Furthermore, the degree of constriction by Adrenochrome is dependent on the CaCl2 concentration in the perfusion medium[1]. |
| References | [1]. M Karmazyn,, et al. Adrenochrome-induced coronary artery constriction in the rat heart. J Pharmacol Exp Ther. 1981 Oct;219(1):225-30. [2]. S Takeo,et al. Effects of adrenochrome on calcium accumulating and adenosine triphosphatase activities of the rat heart microsomes. J Pharmacol Exp Ther. 1980 Sep;214(3):688-93. [3]. Koji Ueda, et al. Catecholamine oxidation-mediated transcriptional inhibition in Mn neurotoxicity. J Toxicol Sci. 2020;45(10):619-624. |
Chemical & Physical Properties
| Density | 1.42g/cm3 |
|---|---|
| Boiling Point | 375.1ºC at 760 mmHg |
| Melting Point | 115-120ºC |
| Molecular Formula | C9H9NO3 |
| Molecular Weight | 179.17300 |
| Flash Point | 180.7ºC |
| Exact Mass | 179.05800 |
| PSA | 57.61000 |
| Index of Refraction | 1.63 |
| InChIKey | RPHLQSHHTJORHI-UHFFFAOYSA-N |
| SMILES | CN1CC(O)C2=CC(=O)C(=O)C=C21 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 106,90,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 128 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 106,90,1956
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| RIDADR | NONH for all modes of transport |
| RTECS | NM1925000 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| adrenochrome |
