CAS 87272-20-6|MEDICA 16

Introduction：Basic information about CAS 87272-20-6|MEDICA 16, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. MEDICA 16 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	MEDICA 16
CAS Number	87272-20-6	Molecular Weight	342.513
Density	1.0±0.1 g/cm3	Boiling Point	485.9±18.0 °C at 760 mmHg
Molecular Formula	C₂₀H₃₈O₄	Melting Point	154-159ºC
MSDS	ChineseUSA	Flash Point	261.8±17.7 °C

Names

Name	3,3,14,14-tetramethylhexadecanedioic acid
Synonym	More Synonyms

MEDICA 16 BiologicalActivity

Description	MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120[1][2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>GPR120Signaling Pathways >>Metabolic Enzyme/Protease >>ATP Citrate LyaseSignaling Pathways >>GPCR/G Protein >>GPR40Research Areas >>Metabolic Disease
References	[1]. Atkinson LL, et al. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats. Diabetes. 2002;51(5):1548-1555. [2]. Hara T, Hirasawa A, Sun Q, et al. Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol. 2009;380(3):247-255.

Description

MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle, and this reduction is accompanied by an increase in insulin sensitivity. MEDICA16 is a selective agonist for GPR40 as well as selective partial agonists for GPR120[1][2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>GPR120Signaling Pathways >>Metabolic Enzyme/Protease >>ATP Citrate LyaseSignaling Pathways >>GPCR/G Protein >>GPR40Research Areas >>Metabolic Disease

References

[1]. Atkinson LL, et al. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats. Diabetes. 2002;51(5):1548-1555.

[2]. Hara T, Hirasawa A, Sun Q, et al. Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch Pharmacol. 2009;380(3):247-255.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	485.9±18.0 °C at 760 mmHg
Melting Point	154-159ºC
Molecular Formula	C₂₀H₃₈O₄
Molecular Weight	342.513
Flash Point	261.8±17.7 °C
Exact Mass	342.277008
PSA	74.60000
LogP	6.44
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.474
InChIKey	HYSMCRNFENOHJH-UHFFFAOYSA-N
SMILES	CC(C)(CCCCCCCCCCC(C)(C)CC(=O)O)CC(=O)O

Safety Information

HS Code	2917190090

Customs

HS Code	2917190090
Summary	2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Synonyms

3,3,14,14-Tetramethylhexanedecanedioic acid

3,3,14,14-tetramethyl-1,16-hexadecanedioic acid

MEDICA 16

Medic-16

3,3,14,14-tetramethyl-hexadecanedioic acid

3,3,14,14-Tetramethylhexadecanedioic acid

Hexadecandioic acid,3,3,14,14-tetramethyl

3,3,14,14-tetramethyl-hexadecane-1,16-dioic acid

Hexadecanedioic acid, 3,3,14,14-tetramethyl-

MFCD00797684

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