CAS 85679-70-5|Osteocalcin (45-49) (human)

Introduction:Basic information about CAS 85679-70-5|Osteocalcin (45-49) (human), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameOsteocalcin (45-49) (human)
CAS Number85679-70-5Molecular Weight581.66000
Density/Boiling Point/
Molecular FormulaC30H39N5O7Melting Point/
MSDSUSAFlash Point/

Names

Name2-[[1-[2-[[2-[(2-amino-3-phenylpropanoyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoic acid
SynonymMore Synonyms

Osteocalcin (45-49) (human) BiologicalActivity

DescriptionBone Gla Protein (45-49) is the 45-49 fragment of gamma-carboxyglutamic acid (GLA)-containing protein from bone (BGP, osteocalcin), which has chemotactic activity in vitro for a number of cells which are found adjacent to endosteal bone surfaces in vivo[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>Others >>Others
In VitroBovine bone Gla protein (BGP) (1 nM-10 μM) exerts chemotactic activity of (0.1 and 1 μM) cultured human breast cancer cells (MDA-MB-231 cells), (1 nM-1 μM) human peripheral blood monocytes, and (1-10 μM) rat osteosarcoma cells with osteoblast-like characteristics[1].
References

[1]. Mundy GR, et al. Chemotactic activity of the gamma-carboxyglutamic acid containing protein in bone. Calcif Tissue Int. 1983;35(2):164-8.  

Chemical & Physical Properties

Molecular FormulaC30H39N5O7
Molecular Weight581.66000
Exact Mass581.28500
PSA191.16000
LogP2.13300
InChIKeyMJAFJCRCGVXXTP-IGRGDXOOSA-N
SMILESCC(C)C(NC(=O)C1CCCN1C(=O)CNC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)Cc1ccccc1)C(=O)O

Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADRNONH for all modes of transport

Synonyms

OSTEOCALCIN,Fragment 45-49
Phe-Tyr-Gly-Pro-Val
Osteocalcin Fragment 45-49 human
FYGPV
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