CAS 146954-74-7|5'-DMT-2'-F-dU

Introduction：Basic information about CAS 146954-74-7|5'-DMT-2'-F-dU, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 5'-DMT-2'-F-dU BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	5'-DMT-2'-F-dU
CAS Number	146954-74-7	Molecular Weight	548.559
Density	1.4±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₃₀H₂₉FN₂O₇	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
Synonym	More Synonyms

5'-DMT-2'-F-dU BiologicalActivity

Description	2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity[1].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Filovirus
In Vitro	2'-Deoxy-5'-O-DMT-2'-fluorouridine (compound 15h) has 100% inhibition against YFV at 20 mM. 2'-Deoxy-5'-O-DMT-2'-fluorouridine proves to be noncytotoxic at concen-trations up to 20 mM[1].
References	[1]. Christopher McGuigan, et al. Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues. ChemistryOpen. 2016 Jan 21;5(3):227-35.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Molecular Formula	C₃₀H₂₉FN₂O₇
Molecular Weight	548.559
Exact Mass	548.195862
PSA	112.01000
LogP	4.83
Appearance of Characters	Powder \| White to Pale Yellow
Index of Refraction	1.647
InChIKey	CSSFZSSZXOCCJB-YULOIDQLSA-N
SMILES	COc1ccc(C(OCC2OC(n3ccc(=O)[nH]c3=O)C(F)C2O)(c2ccccc2)c2ccc(OC)cc2)cc1

Safety Information

Hazard Codes	Xi

Synonyms

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-uridine

DMT-2'-F-dU

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-2'-fluorouridine

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-

HG1172

5'-O-(4,4'-Dimethoxytrityl)-2'-fluoro-2'-deoxyuridine

5'-DMT-2'-F-dU

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