CAS 68076-36-8|NH2-C4-NH-Boc
| Common Name | NH2-C4-NH-Boc | ||
|---|---|---|---|
| CAS Number | 68076-36-8 | Molecular Weight | 188.267 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 292.9±23.0 °C at 760 mmHg |
| Molecular Formula | C9H20N2O2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 130.9±22.6 °C |
| Symbol | GHS05 | Signal Word | Danger |
Names
| Name | tert-Butyl N-(4-aminobutyl)carbamate |
|---|---|
| Synonym | More Synonyms |
NH2-C4-NH-Boc BiologicalActivity
| Description | NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | Alkyl/ether |
| References | [1]. Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 292.9±23.0 °C at 760 mmHg |
| Molecular Formula | C9H20N2O2 |
| Molecular Weight | 188.267 |
| Flash Point | 130.9±22.6 °C |
| Exact Mass | 188.152481 |
| PSA | 64.35000 |
| LogP | 1.06 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.457 |
| InChIKey | ZFQWJXFJJZUVPI-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NCCCCN |
Safety Information
| Symbol | GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H314 |
| Precautionary Statements | P280-P305 + P351 + P338-P310 |
| Personal Protective Equipment | Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | C |
| Risk Phrases | R34 |
| Safety Phrases | S26-S36/37/39-S45 |
| RIDADR | UN 2735 8/PG 3 |
| WGK Germany | 3 |
| Hazard Class | 8.0 |
| HS Code | 2924199090 |
Customs
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles8
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| Synthesis, tubulin binding, antineoplastic evaluation, and structure-activity relationship of oncodazole analogues. J. Med. Chem. 32 , 409, (1989) In an attempt to identify a soluble oncodazole analogue that could be easily formulated, a series of substituted oncodazoles was synthesized and evaluated for tubulin binding affinity, in vitro cytoto... | |
| Synthesis and biological evaluation of new citrate-based siderophores as potential probes for the mechanism of iron uptake in mycobacteria. J. Med. Chem. 45 , 2056, (2002) Several iron chelators containing alpha,beta-unsaturated hydroxamic acid motifs appended to a citric acid platform were synthesized. Mycobacterium paratuberculosis was then challenged to grow in the p... |
Synonyms
| 2-Methyl-2-propanyl (4-aminobutyl)carbamate |
| BOC-NH(CH2)4NH2 HCL |
| tert-butyl 4-aminobutylcarbamate |
| Carbamic acid, N-(4-aminobutyl)-, 1,1-dimethylethyl ester |
| (4-amino-butyl)-carbamic acid tert-butyl ester |
| N-(1,1-dimethylethoxycarbonyl)-1,4-butanediamine |
| BOC-DIAMINOBUTANE HCL |
| N-Boc-1,4-butanediamine |
| N-Boc-1,4-butandiamine |
| N-T-BOC-BUTANDIAMINE HCL |
| (4-aminobutyl)carbamic acid 1,1-dimethylethyl ester |
| BUTTPARK 121 6-09 |
| RARECHEM AR PA 0023 |
| tert-ButylN-(4-aminobutyl)carbamate |
| 4-(t-butoxycarbonylamino)butylamine |
| N-BOC-1,4-DIAMINOBUTANE |
| AURORA KA-4397 |
| N-(tert-butoxycarbonyl)-1,4-diamino-butane |
| BOC-DAB HCL |
| N-tert-Butoxycarbonyl-1,4-butanediamine |
| MFCD02090802 |
| tert-butyl 4-amino butylcarbamate |
