CAS 142439-92-7|NHS-SS-(+)-Biotin

Introduction：Basic information about CAS 142439-92-7|NHS-SS-(+)-Biotin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. NHS-SS-(+)-Biotin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles4
6. Synonyms

Common Name	NHS-SS-(+)-Biotin
CAS Number	142439-92-7	Molecular Weight	575.72200
Density	1.43	Boiling Point	/
Molecular Formula	C₂₂H₃₃N₅O₇S₃	Melting Point	129-131ºC
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS08	Signal Word	Danger

Names

Name	(2,5-dioxopyrrolidin-1-yl) 3-[[3-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethylamino]-3-oxopropyl]disulfanyl]propanoate
Synonym	More Synonyms

NHS-SS-(+)-Biotin BiologicalActivity

Description	Biotin-bis-amido-SS-NHS is an Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog	Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target	Alkyl/ether
In Vitro	Biotin-bis-amido-SS-NHS is a long arm biotin containing disulfide bond, and the compound can be applied to biochemistry detection field, reduce the influence of steric effect, improve the sensitivity of detection[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Liyanping, et al. A kind of long arm biotin containing disulfide bond and preparation method thereof. Patent CN107383054A.

Chemical & Physical Properties

Density	1.43
Melting Point	129-131ºC
Molecular Formula	C₂₂H₃₃N₅O₇S₃
Molecular Weight	575.72200
Exact Mass	575.15400
PSA	238.91000
LogP	2.09070
InChIKey	LWPHUVGDBNUVHA-GXZWQRSESA-N
SMILES	O=C(CCCCC1SCC2NC(=O)NC21)NCCNC(=O)CCSSCCC(=O)ON1C(=O)CCC1=O
Storage condition	-20°C

Safety Information

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360D
Precautionary Statements	P201-P308 + P313
Hazard Codes	T: Toxic;
Risk Phrases	61
Safety Phrases	53-23-36/37/39-45
RIDADR	NONH for all modes of transport

Articles4

Chemical probes of extended biological structures: synthesis and properties of the cleavable protein cross-linking reagent [35S]dithiobis(succinimidyl propionate).

J. Mol. Biol. 104 , 243-261, (1976)

A mechanism-based affinity-labeling agent for possible use in isolating N-acetylglucosaminidase.

Bioorg. Med. Chem. Lett. 11 , 1769-1773, (2001)

We have prepared several mechanism-based affinity-labeling agents for possible use in isolating N-acetylglucosaminidase, in which an N-acetylglucosamine is linked to an o-monofluoro- or difluoro-methy...

A dominant linear B-cell epitope of ricin A-chain is the target of a neutralizing antibody response in Hodgkin's lymphoma patients treated with an anti-CD25 immunotoxin.

Clin. Exp. Immunol. 136 , 365-372, (2004)

Hodgkin's lymphoma patients treated with an anti-CD25 Ricin toxin A-chain (RTA)-based Immunotoxin (RFT5.dgA) develop an immune response against the toxic moiety of the immunoconjugate. The anti-RTA an...

Synonyms

Succinimidyl 3-[3-[2-(biotinamido)ethyl]amino-3-oxopropyl]dithio]propionate

NHS-SS-Biotin

Biotin disulfide N-hydroxysuccinimide ester

(2-[Biotinamido]ethylamido)-3,3 inverted exclamation marka-dithiodipropionic acid N-hydroxysuccinimide ester

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