CAS 67-47-0|5-hydroxymethylfurfural
| Common Name | 5-hydroxymethylfurfural | ||
|---|---|---|---|
| CAS Number | 67-47-0 | Molecular Weight | 126.110 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 291.5±30.0 °C at 760 mmHg |
| Molecular Formula | C6H6O3 | Melting Point | 28-34 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 79.4±0.0 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 5-hydroxymethylfurfural |
|---|---|
| Synonym | More Synonyms |
5-hydroxymethylfurfural BiologicalActivity
| Description | 5-(Hydroxymethyl)furan-2-carbaldehyde, derived from lignocellulosic biomass, inhibits yeast growth and fermentation as stressors. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>FungalNatural Products >>Acids and AldehydesResearch Areas >>Others |
| Target | Yeast[1]. |
| In Vitro | It is found that furfural and HMF cause the attenuation of bulk translation activity and the assembly of cytoplasmic mRNP granules in Saccharomyces cerevisiae. Notably, a combination of furfural and HMF induce the remarkable repression of translation initiation and SG formation. Furfural and HMF can induce the formation of cytoplasmic mRNP granules, HMF also causes a gradual reduction in the polysome fraction and a concomitant increase in the 80S monosome fraction[1]. |
| References | [1]. Iwaki A, et al. Biomass conversion inhibitors furfural and 5-hydroxymethylfurfural induce formation of messenger RNP granules and attenuate translation activity in Saccharomyces cerevisiae. Appl Environ Microbiol. 2013 Mar;79(5):1661-7. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 291.5±30.0 °C at 760 mmHg |
| Melting Point | 28-34 °C(lit.) |
| Molecular Formula | C6H6O3 |
| Molecular Weight | 126.110 |
| Flash Point | 79.4±0.0 °C |
| Exact Mass | 126.031693 |
| PSA | 50.44000 |
| LogP | -0.45 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.563 |
| InChIKey | NOEGNKMFWQHSLB-UHFFFAOYSA-N |
| SMILES | O=Cc1ccc(CO)o1 |
| Storage condition | 2-8°C |
| Stability | Light Sensitive, Very Hygroscopic |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
MUTATION DATA - TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 2 gm/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 227,117,1989
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 2 gm/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 227,117,1989
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | LT7031100 |
| Packaging Group | III |
| HS Code | 2932190090 |
Customs
| HS Code | 2932190090 |
|---|---|
| Summary | 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
Articles87
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Synonyms
| HMF |
| EINECS 200-654-9 |
| 5-(Hydroxymethyl)furan-2-carboxaldehyde |
| T5OJ BVH E1Q |
| 5-(Hydroxymethyl)-2-furancarboxaldehyde |
| 5-(Hydroxymethyl)furan-2-carbaldehyde |
| Aes-103 |
| 5-(Hydroxymethyl)furfural |
| 5-Hydroxymethylfurfural |
| 2-Furancarboxaldehyde, 5-(hydroxymethyl)- |
| MFCD00003234 |
| 2-furaldehyde, 5-(hydroxymethyl)- |
