Introduction：Basic information about CAS 15397-12-3|2'-C-Methyladenosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2'-C-Methyladenosine |
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| CAS Number | 15397-12-3 | Molecular Weight | 281.268 |
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| Density | 1.9±0.1 g/cm3 | Boiling Point | 643.4±65.0 °C at 760 mmHg |
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| Molecular Formula | C11H15N5O4 | Melting Point | / |
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| MSDS | / | Flash Point | 342.9±34.3 °C |
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Names
| Name | (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol |
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| Synonym | More Synonyms |
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2'-C-Methyladenosine BiologicalActivity
| Description | 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[1][2]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>HCVResearch Areas >>InfectionResearch Areas >>Inflammation/Immunology |
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| Target | IC50: 0.3μM (HCV replicon); 1.9 μM (NS5B)[1] |
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| In Vivo | 2'-C-Methyladenosine has inhibitory potency for HCV replicon in HB110A cells with an IC50 values of 0.3μM[1]. 2'-C-Methyladenosine inhibits NS5B-catalyzed RNA synthesis with an IC50 values of 1.9 μM[1]. 2′-C-methyladenosine potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis[2] |
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Chemical & Physical Properties
| Density | 1.9±0.1 g/cm3 |
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| Boiling Point | 643.4±65.0 °C at 760 mmHg |
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| Molecular Formula | C11H15N5O4 |
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| Molecular Weight | 281.268 |
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| Flash Point | 342.9±34.3 °C |
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| Exact Mass | 281.112396 |
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| PSA | 139.54000 |
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| LogP | 0.55 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.823 |
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| InChIKey | PASOFFRBGIVJET-YRKGHMEHSA-N |
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| SMILES | CC1(O)C(O)C(CO)OC1n1cnc2c(N)ncnc21 |
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Synonyms
| 2'-C-Methyladenosine |
| 2-(6-amino-purin-9-yl)-5-hydroxymethyl-3-methyl-tetrahydrofuran-3,4-diol |
| 2'-METHYLADENOSINE |
| 2'-C-methyl adenosine |
| Adenosine, 2'-C-methyl- |
