Introduction：Basic information about CAS 128322-44-1|MCLA hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MCLA hydrochloride |
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| CAS Number | 128322-44-1 | Molecular Weight | 291.733 |
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| Density | / | Boiling Point | 410.3ºC at 760 mmHg |
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| Molecular Formula | C14H14ClN3O2 | Melting Point | / |
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| MSDS | USA | Flash Point | 201.9ºC |
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Names
| Name | 2-Methyl-6-(4-Methoxyphenyl)-3,7-Dihydroimidazo[1,2-a]Pyrazin-3-One Hydrochloride |
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| Synonym | More Synonyms |
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MCLA hydrochloride BiologicalActivity
| Description | MCLA hydrochloride is a chemiluminescent reagent which can be used to quantify aqueous concentrations of superoxide. |
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| Related Catalog | Signaling Pathways >>Others >>OthersDye ReagentsResearch Areas >>Others |
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| In Vitro | The non-specific luminescence remains almost constant for 10 min after the addition of MCLA hydrochloride (MCLA) and is not significantly influenced by SOD. The MCLA hydrochloride method is, however, 4.5-times more sensitive than the CLA method[1]. |
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| Kinase Assay | The standard reaction mixture contains 1×l0-7 M MCLA hydrochloride (MCLA), 5×10-5 M hypoxanthine, XOD (6.5 U), SOD (0.2 to 20 ng/mL) or none, and 50 mM Tris-HCl buffer containing 0.1 mM EDTA at pH 7.8, in a total volume of 3.0 mL. Chemiluminescence measurement is initiated by the addition of MCLA hydrochloride to the standard incubation mixture excluding XOD, continued for 4 min without additive and for an additional 4 min after the addition of XOD. Chemiluminescence is measured using a luminescence reader at 25°C[1]. |
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| References | [1]. Kimura H, et al. Highly sensitive and reliable chemiluminescence method for the assay of superoxide dismutase inhuman erythrocytes. FEBS Lett. 1988 Nov 7;239(2):347-50. |
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Chemical & Physical Properties
| Boiling Point | 410.3ºC at 760 mmHg |
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| Molecular Formula | C14H14ClN3O2 |
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| Molecular Weight | 291.733 |
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| Flash Point | 201.9ºC |
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| Exact Mass | 291.077454 |
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| PSA | 59.39000 |
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| LogP | 2.80860 |
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| Vapour Pressure | 3.95E-07mmHg at 25°C |
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| InChIKey | MXZACTZQSGYANA-UHFFFAOYSA-N |
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| SMILES | COc1ccc(-c2cn3c(O)c(C)nc3cn2)cc1.Cl |
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| Storage condition | 2~8°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | F+ |
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| Safety Phrases | S22 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3.0 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-Methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one Hydrochloride |
| 6-(4-Methoxyphenyl)-2-methyl-3,7-dihydroimidazo[1,2-a]pyrazin-3(7H)-one hydrochloride |
| 6-(4-methoxyphenyl)-2-methyl-7H-imidazo[1,2-a]pyrazin-3-one,hydrochloride |
| MFCD00144728 |
| 6-(4-Methoxyphenyl)-2-methylimidazo[1,2-a]pyrazin-3(7H)-one hydrochloride (1:1) |
| Imidazo[1,2-a]pyrazin-3(7H)-one, 6-(4-methoxyphenyl)-2-methyl-, hydrochloride (1:1) |
| 6-(4-Methoxyphenyl)-2-methyl-3,7-dihydroimidazo[1,2-a]pyrazin-3-one Hydrochloride |
| 6-(4-Methoxyphenyl)-2-methylimidazo[1,2-a]pyrazin-3(7H)-one hydrochloride |
| MCLA hydrochloride |
