CAS 5560-59-8|Alverine citrate
Introduction：Basic information about CAS 5560-59-8|Alverine citrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Alverine citrate | ||
|---|---|---|---|
| CAS Number | 5560-59-8 | Molecular Weight | 473.55900 |
| Density | / | Boiling Point | 358.8ºC at 760mmHg |
| Molecular Formula | C26H35NO7 | Melting Point | / |
| MSDS | USA | Flash Point | 174.4ºC |
Names
| Name | alverine citrate |
|---|---|
| Synonym | More Synonyms |
Alverine citrate BiologicalActivity
| Description | Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorResearch Areas >>Metabolic Disease |
| Target | 5-HT1A Receptor:101 nM (IC50) |
| In Vitro | Alverine is a drug used for functional gastrointestinal disorders. Alverine acts directly on the muscle in the gut, causing it to relax. Alverine Citrate (20 mg/kg) suppresses the effect of 5-HTP, but not that of 8-OH-DPAT. However, when injected intracerebroventricularly (75 μg/rat) alverine citrate reduces 8-OH-DPAT-induced enhancement of rectal distension-induced abdominal contractions. In-vitro binding studies reveal that Alverine citrate has a high affinity for 5-HT1A receptors and a weak affinity for 5-HT3 and 5-HT4 subtypes[1]. Alverine may increase Ca influx during action potentials due to inhibition of the inactivation of L-type Ca channels, but may also suppress evoked activity by inhibiting the sensitivity of contractile proteins to Ca2+[2]. |
| References | [1]. Coelho, A.M., et al., Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol, 2001. 53(10): p. 1419-26. [2]. Hayase, M., et al., Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol, 2007. 152(8): p. 1228-38. |
Chemical & Physical Properties
| Boiling Point | 358.8ºC at 760mmHg |
|---|---|
| Molecular Formula | C26H35NO7 |
| Molecular Weight | 473.55900 |
| Flash Point | 174.4ºC |
| Exact Mass | 473.24100 |
| PSA | 135.37000 |
| LogP | 3.32540 |
| InChIKey | RYHCACJBKCOBTJ-UHFFFAOYSA-N |
| SMILES | CCN(CCCc1ccccc1)CCCc1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2921499090 |
Customs
| HS Code | 2921499090 |
|---|---|
| Summary | 2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Articles17
More Articles| Validated LC-MS/MS method for determination of Alverine and one of its hydroxy metabolites in human plasma along with its application to a bioequivalence study. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 197-206, (2009) The present research work involves a first of its kind rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method developed and validated for simultaneous analysis of Alverin... | |
| A general practice study to compare alverine citrate with mebeverine hydrochloride in the treatment of irritable bowel syndrome. Br. J. Clin. Pract. 40(7) , 276-8, (1986) | |
| Alverine citrate, simeticone, and Rome III irritable bowel syndrome. Aliment. Pharmacol. Ther. 31(7) , 767-8; author reply 768-9, (2010) |
Synonyms
| N-ethyl-3-phenyl-N-(3-phenylpropyl)propan-1-amine,2-hydroxypropane-1,2,3-tricarboxylic acid |
| MFCD00035086 |
| EINECS 226-929-3 |
| Alverine Citrate |
| Alverine (citrate) |
