CAS 114-86-3|phenformin

Introduction：Basic information about CAS 114-86-3|phenformin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. phenformin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	phenformin
CAS Number	114-86-3	Molecular Weight	205.260
Density	1.2±0.1 g/cm3	Boiling Point	332.2±35.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₅N₅	Melting Point	280-282°C
MSDS	/	Flash Point	154.7±25.9 °C

Names

Name	phenformin
Synonym	More Synonyms

phenformin BiologicalActivity

Description	Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].
Related Catalog	Signaling Pathways >>Epigenetics >>AMPKSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>AMPKResearch Areas >>Metabolic Disease
References	[1]. García Rubiño ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019 Jul 5;20(13):3316. [2]. Yendapally R, et al. A review of phenformin, metformin, and imeglimin. Drug Dev Res. 2020 Jun;81(4):390-401.

Description

Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].

Related Catalog

Signaling Pathways >>Epigenetics >>AMPKSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>AMPKResearch Areas >>Metabolic Disease

References

[1]. García Rubiño ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019 Jul 5;20(13):3316.

[2]. Yendapally R, et al. A review of phenformin, metformin, and imeglimin. Drug Dev Res. 2020 Jun;81(4):390-401.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	332.2±35.0 °C at 760 mmHg
Melting Point	280-282°C
Molecular Formula	C₁₀H₁₅N₅
Molecular Weight	205.260
Flash Point	154.7±25.9 °C
Exact Mass	205.132751
PSA	97.78000
LogP	-0.60
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.620
InChIKey	ICFJFFQQTFMIBG-UHFFFAOYSA-N
SMILES	NC(N)=NC(N)=NCCc1ccccc1
Storage condition	2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU2100000

CHEMICAL NAME :: Biguanide, 1-phenethyl-

CAS REGISTRY NUMBER :: 114-86-3

BEILSTEIN REFERENCE NO. :: 1977317

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H15-N5

MOLECULAR WEIGHT :: 205.30

WISWESSER LINE NOTATION :: MUYZMYUM&M2R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 42,236,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 42,236,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 97,396,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 8,237,1963

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - metabolic acidosis

REFERENCE :: 43ZRAD "Hemoperfusion: Kidney and Liver Support and Detoxification, Proceedings of the International Symposium, Haifa, 1979," Sideman, S., and T.M.S. Chang, eds., Multiple parts, New York, Hemisphere Pub. Corp., 1980- Volume(issue)/page/year: 1,337,1980

Safety Information

Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S36
WGK Germany	3
RTECS	DU2200000

Synonyms

[3H]-Phenformin

Fenformin

Normoglucina

1-(diaminomethylidene)-2-(2-phenylethyl)guanidine

[14C]-Phenformin

1-phenethylbiguanide

MFCD00035039

Imidodicarbonimidic diamide, N-(2-phenylethyl)-

Feguanide

Phenforminum

phenylethyl biguanide

phenethylbiguanide

Phenformine

EINECS 204-057-4

phenformin

Cronoformin

Fenfoduron

Fenformina

N-(2-Phenylethyl)imidodicarbonimidic diamide

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