CAS 850-52-2|Altrenogest

Introduction：Basic information about CAS 850-52-2|Altrenogest, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Altrenogest BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Altrenogest
CAS Number	850-52-2	Molecular Weight	310.430
Density	1.1±0.1 g/cm3	Boiling Point	495.6±45.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₆O₂	Melting Point	120ºC
MSDS	/	Flash Point	210.1±21.3 °C

Names

Name	Altrenogest
Synonym	More Synonyms

Altrenogest BiologicalActivity

Description	Altrenogest(A35957; RU2267) is a progestogen structurally related to veterinary steroid trenbolone.Target: Progesterone ReceptorAltrenogest is a progestogen structurally related to veterinary steroid trenbolone. Treatment of embryo-recipient mares with altrenogest appears to be beneficial in extending the degree of donor-recipient synchrony required for successful embryo transfer. Altrenogest treatment also seems to be conductive to pregnancy maintenance in recipients experiencing luteal dysfunction [1]. The oil and gel altrenogest preparations are equally effective in modulating estrous behavior and time to estrus and ovulation. Altrenogest treatment started late in diestrus appears to result in a high incidence of ovulation during treatment and when luteolysis and ovulation occur during treatment; the subsequent luteal phase is frequently prolonged due to failure of regression of the CL [2].
Related Catalog	Signaling Pathways >>Others >>Progesterone ReceptorResearch Areas >>Endocrinology
References	[1]. Parry-Weeks, L.C. and D.W. Holtan, Effect of altrenogest on pregnancy maintenance in unsynchronized equine embryo recipients. J Reprod Fertil Suppl, 1987. 35: p. 433-8. [2]. Daels, P.F., et al., Persistence of the luteal phase following ovulation during altrenogest treatment in mares. Theriogenology, 1996. 46(5): p. 799-811.

Description

Altrenogest(A35957; RU2267) is a progestogen structurally related to veterinary steroid trenbolone.Target: Progesterone ReceptorAltrenogest is a progestogen structurally related to veterinary steroid trenbolone. Treatment of embryo-recipient mares with altrenogest appears to be beneficial in extending the degree of donor-recipient synchrony required for successful embryo transfer. Altrenogest treatment also seems to be conductive to pregnancy maintenance in recipients experiencing luteal dysfunction [1]. The oil and gel altrenogest preparations are equally effective in modulating estrous behavior and time to estrus and ovulation. Altrenogest treatment started late in diestrus appears to result in a high incidence of ovulation during treatment and when luteolysis and ovulation occur during treatment; the subsequent luteal phase is frequently prolonged due to failure of regression of the CL [2].

Related Catalog

Signaling Pathways >>Others >>Progesterone ReceptorResearch Areas >>Endocrinology

References

[1]. Parry-Weeks, L.C. and D.W. Holtan, Effect of altrenogest on pregnancy maintenance in unsynchronized equine embryo recipients. J Reprod Fertil Suppl, 1987. 35: p. 433-8.

[2]. Daels, P.F., et al., Persistence of the luteal phase following ovulation during altrenogest treatment in mares. Theriogenology, 1996. 46(5): p. 799-811.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	495.6±45.0 °C at 760 mmHg
Melting Point	120ºC
Molecular Formula	C₂₁H₂₆O₂
Molecular Weight	310.430
Flash Point	210.1±21.3 °C
Exact Mass	310.193268
PSA	37.30000
LogP	3.49
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.594
InChIKey	VWAUPFMBXBWEQY-ANULTFPQSA-N
SMILES	C=CCC1(O)CCC2C3CCC4=CC(=O)CCC4=C3C=CC21C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG7745000

CHEMICAL NAME :: Estra-4,9,11-trien-3-one, 17-alpha-allyl-17-hydroxy-

CAS REGISTRY NUMBER :: 850-52-2

LAST UPDATED :: 199509

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H26-O2

MOLECULAR WEIGHT :: 310.47

WISWESSER LINE NOTATION :: L E5 B666 OV AU CU MUTJ E1 FQ F2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 mg/kg

SEX/DURATION :: female 18 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 16,195,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 ug/kg

SEX/DURATION :: female 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 70,1357,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 810 ug/kg

SEX/DURATION :: female 15 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Maternal Effects - other effects

REFERENCE :: JRFSAR Journal of Reproduction and Fertility, Supplement. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) No.1- 1966- Volume(issue)/page/year: 32,193,1982

Safety Information

WGK Germany	3.0
RTECS	KG7745000
HS Code	2937290090

Customs

HS Code	2937290090

Synonyms

(17b)-17-Hydroxy-17-(2-propenyl)estra-4,9,11-trien-3-one

13b-Methyl-17a-allyl-D4,9,11-gonatriene-17b-ol-3-one

(17β)-17-Hydroxy-17-(2-propenyl)estra-4,9,11-trien-3-one

Estra-4,9,11-trien-3-one, 17-hydroxy-17-(2-propen-1-yl)-, (17β)-

Allyltrenbolone

r2267

17α-Allyl-17-hydroxyestra-4,9,11-trien-3-one

altregonest

(17β)-17-hydroxy-17-(prop-2-en-1-yl)estra-4,9,11-trien-3-one

Altrenogest

REGU-MATE

17-allyltrenbolone

ru2267

Estra-4,9,11-trien-3-one, 17-α-allyl-17-hydroxy-

(8S,13S,14S,17R)-17-Allyl-17-hydroxy-13-methyl-1,2,6,7,8,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one

drc6246

Estra-4,9,11-trien-3-one, 17β-hydroxy-17-(2-propenyl)-

Regumate

17a-Allyl-17-hydroxyestra-4,9,11-trien-3-one

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