Introduction：Basic information about CAS 3073-59-4|Hexamethylene bisacetamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hexamethylene bisacetamide |
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| CAS Number | 3073-59-4 | Molecular Weight | 200.28 |
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| Density | 0.974 g/cm3 | Boiling Point | 456.7ºC at 760 mmHg |
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| Molecular Formula | C10H20N2O2 | Melting Point | 128-129 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 193.2ºC |
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Names
| Name | N-(6-acetamidohexyl)acetamide |
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| Synonym | More Synonyms |
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Hexamethylene bisacetamide BiologicalActivity
| Description | Hexamethylene bisacetamide is a tumor cell-differentiating agent[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| References | [1]. Reuben RC, et al. A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc Natl Acad Sci U S A. 1976 Mar;73(3):862-6. |
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Chemical & Physical Properties
| Density | 0.974 g/cm3 |
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| Boiling Point | 456.7ºC at 760 mmHg |
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| Melting Point | 128-129 °C(lit.) |
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| Molecular Formula | C10H20N2O2 |
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| Molecular Weight | 200.28 |
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| Flash Point | 193.2ºC |
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| Exact Mass | 200.15200 |
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| PSA | 58.20000 |
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| LogP | 1.60080 |
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| InChIKey | BNQSTAOJRULKNX-UHFFFAOYSA-N |
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| SMILES | CC(=O)NCCCCCCNC(C)=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AC2976200
- CHEMICAL NAME :
- Acetamide, N,N'-hexamethylenebis-
- CAS REGISTRY NUMBER :
- 3073-59-4
- BEILSTEIN REFERENCE NO. :
- 1775764
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C10-H20-N2-O2
- MOLECULAR WEIGHT :
- 200.32
- WISWESSER LINE NOTATION :
- 1VM6MV1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 4270 mg/kg/10D-C
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Blood - thrombocytopenia
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,5788,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3250 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4100 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Risk Phrases | R33:Danger of cumulative effects. |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | AC2976200 |
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| HS Code | 2924199090 |
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Customs
| HS Code | 2924199090 |
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| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| N,N‘-Hexamethylenebisacetamide |
| N,N'-hexamethylene bis(acetamide) |
| Hexamethylenediacetamide |
| N,N'-diacetyl-1,6-hexanediamine |
| hmba |
| N,N′-Diacetyl-1,6-diaminohexane |
| diacetyldiaminohexane |
| EINECS 211-363-1 |
| hexamethylenebis(acetamide) |
| N,N-Hexamethylenediacetamide |
| N,N'-DIACETYL-1,6-DIAMINOHEXANE |
| MFCD00008684 |
