CAS 837-52-5|7-Chloro-4-(piperazin-1-yl)quinoline

Introduction：Basic information about CAS 837-52-5|7-Chloro-4-(piperazin-1-yl)quinoline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 7-Chloro-4-(piperazin-1-yl)quinoline BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	7-Chloro-4-(piperazin-1-yl)quinoline
CAS Number	837-52-5	Molecular Weight	247.72300
Density	1.257 g/cm3	Boiling Point	433.5ºC at 760 mmHg
Molecular Formula	C₁₃H₁₄ClN₃	Melting Point	113-116ºC
MSDS	/	Flash Point	216ºC

Names

Name	7-Chloro-4-(piperazin-1-yl)quinoline
Synonym	More Synonyms

7-Chloro-4-(piperazin-1-yl)quinoline BiologicalActivity

Description	7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively[1].
Related Catalog	Signaling Pathways >>Epigenetics >>SirtuinResearch Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>Sirtuin
References	[1]. Aida M Abd El-Sattar El-Azzouny, et al. Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives. Drug Dev Res. 2020 Nov;81(7):786-802.

Chemical & Physical Properties

Density	1.257 g/cm3
Boiling Point	433.5ºC at 760 mmHg
Melting Point	113-116ºC
Molecular Formula	C₁₃H₁₄ClN₃
Molecular Weight	247.72300
Flash Point	216ºC
Exact Mass	247.08800
PSA	28.16000
LogP	2.69160
Index of Refraction	1.636
InChIKey	DNXNPMDUDGUXOB-UHFFFAOYSA-N
SMILES	Clc1ccc2c(N3CCNCC3)ccnc2c1
Storage condition	2-8°C

Safety Information

Hazard Codes	C: Corrosive;
Risk Phrases	R34
Safety Phrases	S22-S26-S36/37/39-S45
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

7-chloro-4-piperazin-1-ylquinoline

Recommended......