Introduction：Basic information about CAS 142253-55-2|1-Boc-azetidine-3-carboxylic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-Boc-azetidine-3-carboxylic acid |
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| CAS Number | 142253-55-2 | Molecular Weight | 201.220 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 321.0±35.0 °C at 760 mmHg |
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| Molecular Formula | C9H15NO4 | Melting Point | 100.1-101.9°C |
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| MSDS | ChineseUSA | Flash Point | 147.9±25.9 °C |
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Names
| Name | 1-Boc-3-Azetidine-3-carboxylic acid |
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| Synonym | More Synonyms |
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1-Boc-azetidine-3-carboxylic acid BiologicalActivity
| Description | 1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 321.0±35.0 °C at 760 mmHg |
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| Melting Point | 100.1-101.9°C |
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| Molecular Formula | C9H15NO4 |
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| Molecular Weight | 201.220 |
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| Flash Point | 147.9±25.9 °C |
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| Exact Mass | 201.100113 |
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| PSA | 66.84000 |
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| LogP | 0.27 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.510 |
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| InChIKey | NCADHSLPNSTDMJ-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)OC(=O)N1CC(C(=O)O)C1 |
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| Storage condition | Store at -15°C |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | 36/37/38 |
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| Safety Phrases | S22-S24/25-S37-S26 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-3-azetidinecarboxylic acid |
| 1-N-Boc-3-Azetidinecarboxylic Acid |
| 1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-3-carboxylic acid |
| MFCD01860897 |
| 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid |
| N-Boc-Azetidine-3-carboxylic acid |
| 1-BOC-Azetidine-3-carboxylic acid |
| 1-Boc-azetidine-3-carboxylicacid |
