CAS 128117-22-6|1-Cbz-3-Hydroxyazetidine

Introduction：Basic information about CAS 128117-22-6|1-Cbz-3-Hydroxyazetidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name1-Cbz-3-Hydroxyazetidine
CAS Number128117-22-6Molecular Weight207.226
Density1.3±0.1 g/cm3Boiling Point356.7±42.0 °C at 760 mmHg
Molecular FormulaC11H13NO3Melting Point/
MSDS/Flash Point169.5±27.9 °C

Names

NameBenzyl 3-Hydroxyazetidine-1-Carboxylate
SynonymMore Synonyms

1-Cbz-3-Hydroxyazetidine BiologicalActivity

Description1-Cbz-3-Hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-3-Hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
Related CatalogResearch Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

Non-cleavable

In VitroADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

Density1.3±0.1 g/cm3
Boiling Point356.7±42.0 °C at 760 mmHg
Molecular FormulaC11H13NO3
Molecular Weight207.226
Flash Point169.5±27.9 °C
Exact Mass207.089539
PSA49.77000
LogP0.45
Vapour Pressure0.0±0.8 mmHg at 25°C
Index of Refraction1.608
InChIKeyXJWSNDGCJMGHSR-UHFFFAOYSA-N
SMILESO=C(OCc1ccccc1)N1CC(O)C1
Storage condition2-8°C

Safety Information

Hazard CodesXi

Synonyms

1-Cbz-3-Hydroxyazetidine
1-Azetidinecarboxylic acid,3-hydroxy-,phenylmethyl ester
1-Azetidinecarboxylic acid, 3-hydroxy-, phenylmethyl ester
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