CAS 534-07-6|1,3-Dichloroacetone
Introduction：Basic information about CAS 534-07-6|1,3-Dichloroacetone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1,3-Dichloroacetone | ||
|---|---|---|---|
| CAS Number | 534-07-6 | Molecular Weight | 126.969 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 173.0±0.0 °C at 760 mmHg |
| Molecular Formula | C3H4Cl2O | Melting Point | 43 °C |
| MSDS | ChineseUSA | Flash Point | 89.4±0.0 °C |
| Symbol | GHS05, GHS06, GHS08 | Signal Word | Danger |
Names
| Name | 1,3-Dichloroacetone |
|---|---|
| Synonym | More Synonyms |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 173.0±0.0 °C at 760 mmHg |
| Melting Point | 43 °C |
| Molecular Formula | C3H4Cl2O |
| Molecular Weight | 126.969 |
| Flash Point | 89.4±0.0 °C |
| Exact Mass | 125.963921 |
| PSA | 17.07000 |
| LogP | 1.29 |
| Vapour density | 4.38 (vs air) |
| Vapour Pressure | 1.3±0.3 mmHg at 25°C |
| Index of Refraction | 1.437 |
| InChIKey | SUNMBRGCANLOEG-UHFFFAOYSA-N |
| SMILES | O=C(CCl)CCl |
| Water Solubility | 27.9 g/L (20 º C) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18900 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 53 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - iritis Behavioral - somnolence (general depressed activity)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 720 mg/kg/90D-C
- TOXIC EFFECTS :
- Behavioral - fluid intake Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 37500 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA - TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 2 umol/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 2 umol/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9,401,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993
Safety Information
| Symbol | GHS05, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330-H314-H341 |
| Precautionary Statements | P260-P264-P280-P284-P301 + P310-P302 + P350 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+:Verytoxic; |
| Risk Phrases | R24;R26/28;R36/37/38;R68 |
| Safety Phrases | S26-S36/37/39-S45-S28A-S1 |
| RIDADR | UN 3286 3/PG 2 |
| WGK Germany | 3 |
| RTECS | UC1430000 |
| Packaging Group | II |
| Hazard Class | 6.1 |
| HS Code | 29147090 |
Customs
| HS Code | 2914700090 |
|---|---|
| Summary | HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |
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| In vitro metabolism and bioactivation of 1,2,3-trichloropropane. Toxicol. Appl. Pharmacol. 113(1) , 152-8, (1992) In vitro studies using rat and human hepatic microsomes have shown that the halogenated hydrocarbon 1,2,3-trichloropropane (TCP) is bioactivated to the direct acting mutagen 1,3-dichloroacetone (DCA).... | |
| Effects of pH and temperature on the degradation of chloroacetones that are mutagenic. Bull. Environ. Contam. Toxicol. 39(3) , 549-54, (1987) |
Synonyms
| 2-Propanone, 1,3-dichloro- |
| 1,3-Dichloropropan-2-one |
| MFCD00000937 |
| 1,3-Dichloroacetone |
| monochloromethyl ketone |
| 1,3-dichloropropanone |
| EINECS 208-585-6 |
| 4,4'-Dimethoxystilbendichlorid |
| 1,3-dichloro acetone |
| 1,3-dichloro-2-propanone |
