Introduction：Basic information about CAS 85-31-4|6-Thioguanosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 6-Thioguanosine |
|---|
| CAS Number | 85-31-4 | Molecular Weight | 299.31 |
|---|
| Density | 2.18 g/cm3 | Boiling Point | 756.9ºC at 760 mmHg |
|---|
| Molecular Formula | C10H13N5O4S | Melting Point | 230-231°C |
|---|
| MSDS | / | Flash Point | 411.6ºC |
|---|
Names
| Name | 6-thioguanosine |
|---|
| Synonym | More Synonyms |
|---|
6-Thioguanosine BiologicalActivity
| Description | 6-Thioguanosine (6-Mercaptoguanosine), an active nucleoside, is an Azathioprine metabolite. 6-Thioguanosine has immunosuppressive effects[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
|---|
| References | [1]. Amedeo De Nicolò, et al. UPLC-MS/MS method for quantification of the azathioprine metabolites 6-mercaptoguanosine and 6-methylmercaptopurine riboside in peripheral blood mononuclear cells. J Pharm Biomed Anal. 2014 Sep;98:271-8. |
|---|
Chemical & Physical Properties
| Density | 2.18 g/cm3 |
|---|
| Boiling Point | 756.9ºC at 760 mmHg |
|---|
| Melting Point | 230-231°C |
|---|
| Molecular Formula | C10H13N5O4S |
|---|
| Molecular Weight | 299.31 |
|---|
| Flash Point | 411.6ºC |
|---|
| Exact Mass | 299.06900 |
|---|
| PSA | 174.53000 |
|---|
| InChIKey | OTDJAMXESTUWLO-UUOKFMHZSA-N |
|---|
| SMILES | Nc1nc(=S)c2ncn(C3OC(CO)C(O)C3O)c2[nH]1 |
|---|
| Storage condition | -20°C Freezer |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UP0200000
- CHEMICAL NAME :
- 9H-Purine-6-thiol, 2-amino-9-beta-D-ribofuranosyl-
- CAS REGISTRY NUMBER :
- 85-31-4
- LAST UPDATED :
- 199410
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C10-H13-N5-O4-S
- MOLECULAR WEIGHT :
- 299.34
- WISWESSER LINE NOTATION :
- T56 BN DN FN HNJ GZ ISH D- BT5OTJ CQ DQ E1Q
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 3,181,1968
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 156 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD10 - Lethal Dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 7,69,1970 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975
|
Safety Information
| Risk Phrases | 24/25 |
|---|
| RTECS | UP0200000 |
|---|
| HS Code | 2934999090 |
|---|
Customs
| HS Code | 2934999090 |
|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|---|
Synonyms
| 2-amino-6-mercaptopurine ribose |
| thioguanosine |
| sri759 |
| EINECS 201-597-2 |
| 6-MERCAPTOGUANOSINE |
| 6-thio-guanosine |
| 6-thioguanineribose |
| ribosylthioguanine |
| 6-thio-guanosin |
| 2-AMINO-6-MERCAPTOPURINE-9-D-RIBOSIDE HYDRATE |
| MFCD00005736 |
| thioguanineriboside |
| TGR |
