CAS 83373-60-8|D609
| Common Name | D609 | ||
|---|---|---|---|
| CAS Number | 83373-60-8 | Molecular Weight | 266.465 |
| Density | 1.24 g/cm3 | Boiling Point | 303.8ºC at 760 mmHg |
| Molecular Formula | C11H15KOS2 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 137.5ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | D609,O-(Octahydro-4,7-methano-1H-inden-5-yl)carbonopotassiumdithioate |
|---|---|
| Synonym | More Synonyms |
D609 BiologicalActivity
| Description | D609 is a selective competitive inhibitor of phosphatidyl choline-specific phospholipase C (PC-PLC), with Ki of 6.4 μM. |
|---|---|
| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>PhospholipaseResearch Areas >>Cancer |
| Target | Ki: 6.4 μM (PC-PLC) |
| References | [1]. Kalluri HS, et al. D609 inhibits the proliferation of neural progenitor cells.Neuroreport. 2010 Jul 14;21(10):700-3. [2]. Milhas D, et al. The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase-Dependent and -Independent Cell Death in T Lymphocytes.Int J Mol Sci. 2012;13(7):8834-52. Epub 2012 Jul 16. [3]. Gusain A, et al. Anti-proliferative effects of tricyclodecan-9-yl-xanthogenate (D609) involve ceramide and cell cycle inhibition.Mol Neurobiol. 2012 Jun;45(3):455-64. Epub 2012 Mar 14. |
Chemical & Physical Properties
| Density | 1.24 g/cm3 |
|---|---|
| Boiling Point | 303.8ºC at 760 mmHg |
| Molecular Formula | C11H15KOS2 |
| Molecular Weight | 266.465 |
| Flash Point | 137.5ºC |
| Exact Mass | 266.020142 |
| PSA | 66.62000 |
| LogP | 3.31010 |
| InChIKey | YFUFHKMDCZBHMY-UHFFFAOYSA-N |
| SMILES | S=C(S)OC1CC2CC1C1CCCC21.[K] |
| Storage condition | 2-8℃ |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| RIDADR | NONH for all modes of transport |
Articles39
More Articles| Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation. Biochim. Biophys. Acta 1841(12) , 1672-82, (2015) Most anti-cancer agents induce apoptosis, however, a development of multidrug resistance in cancer cells and defects in apoptosis contribute often to treatment failure. Here, the mechanism of curcumin... | |
| Mycobacterium abscessus phospholipase C expression is induced during coculture within amoebae and enhances M. abscessus virulence in mice. Infect. Immun. 83(2) , 780-91, (2015) Mycobacterium abscessus is a pathogenic, rapidly growing mycobacterium involved in pulmonary and cutaneo-mucous infections worldwide, to which cystic fibrosis patients are exquisitely susceptible. The... | |
| Oxidative Stress Increases Surface Toll-Like Receptor 4 Expression in Murine Macrophages Via Ceramide Generation. Shock 44 , 157-65, (2015) Multiorgan failure is a major cause of late mortality following trauma. Oxidative stress generated during shock/resuscitation contributes to tissue injury by priming the immune system for an exaggerat... |
Synonyms
| Tricyclodecan-9-yl xanthate potassium salt |
| D609 |
| Carbonodithioic acid, O-(octahydro-4,7-methano-1H-inden-5-yl) ester, potassium salt (1:1) |
| TRICYCLODECAN-9-YL XANTHOGENATE K |
| potassium O-(octahydro-1H-4,7-methanoinden-5-yl) carbonodithioate |
| Potassium O-tricyclo[5.2.1.0]dec-8-yl carbonodithioate |
| tricyclodecane-9-yl-xanthogenate |
| D-609 POTASSIUM |
| Carbonodithioic acid, O-(octahydro-4,7-methano-1H-inden-5-yl) ester, potassium salt |
| Tricyclodecan-9-yl xanthate |
| MFCD00171401 |
| EINECS 280-379-9 |
| D609 POTASSIUM SALT |
| Tricyclodecan-9-yl xanthogenate |
