CAS 120066-38-8|CRF (6-33)

Introduction：Basic information about CAS 120066-38-8|CRF (6-33), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. CRF (6-33) BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles2
6. Synonyms

Common Name	CRF (6-33)
CAS Number	120066-38-8	Molecular Weight	3220.66000
Density	/	Boiling Point	/
Molecular Formula	C₁₄₁H₂₃₁N₄₁O₄₃S	Melting Point	/
MSDS	USA	Flash Point	/

Names

Name	Corticotropin Releasing Factor Fragment 6-33 human, rat
Synonym	More Synonyms

CRF (6-33) BiologicalActivity

Description	CRF(6-33)(human) is a CRF binding protein (CRF-BP) ligand inhibitor. CRF(6-33)(human) competitively binds the CRF-BP but not the post-synaptic CRF receptors. CRF(6-33)(human) has anti-obesity effect[1][2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>CRFRResearch Areas >>Neurological Disease
References	[1]. S C Heinrichs, et al. Dissociation of arousal-like from anxiogenic-like actions of brain corticotropin-releasing factor receptor ligands in rats. Behav Brain Res. 2001 Jul;122(1):43-50. [2]. S C Heinrichs, et al. Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Physiol Behav. 2001 Sep 1-15;74(1-2):5-13.

Description

CRF(6-33)(human) is a CRF binding protein (CRF-BP) ligand inhibitor. CRF(6-33)(human) competitively binds the CRF-BP but not the post-synaptic CRF receptors. CRF(6-33)(human) has anti-obesity effect[1][2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>CRFRResearch Areas >>Neurological Disease

References

[1]. S C Heinrichs, et al. Dissociation of arousal-like from anxiogenic-like actions of brain corticotropin-releasing factor receptor ligands in rats. Behav Brain Res. 2001 Jul;122(1):43-50.

[2]. S C Heinrichs, et al. Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Physiol Behav. 2001 Sep 1-15;74(1-2):5-13.

Chemical & Physical Properties

Molecular Formula	C₁₄₁H₂₃₁N₄₁O₄₃S
Molecular Weight	3220.66000
Exact Mass	3218.69000
PSA	1394.64000
LogP	3.96850

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Articles2

Neurobiology of corticotropin releasing factor (CRF) receptors and CRF-binding protein: implications for the treatment of CNS disorders.

Mol. Psychiatry 1 , 265-277, (1996)

The actions of CRF in the brain and in the periphery are mediated through multiple binding sites. There are three receptors, CRF1, CRF2 alpha and CRF2 beta, which encode 411, 415 and 431 amino acid pr...

Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal.

Proc. Natl. Acad. Sci. U. S. A. 93 , 15475-15480, (1996)

Elevation of the neuropeptide corticotropin-releasing factor (CRF) in the brain is associated with a reduction of food intake and body weight gain in normal and obese animals. A protein that binds CRF...

Synonyms

MFCD00671436

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