CAS 67469-78-7|Vanoxerine dihydrochloride
| Common Name | Vanoxerine dihydrochloride | ||
|---|---|---|---|
| CAS Number | 67469-78-7 | Molecular Weight | 523.485 |
| Density | / | Boiling Point | 542.7ºC at 760 mmHg |
| Molecular Formula | C28H34Cl2F2N2O | Melting Point | 221 °C |
| MSDS | USA | Flash Point | 282ºC |
Names
| Name | vanoxerine dihydrochloride |
|---|---|
| Synonym | More Synonyms |
Vanoxerine dihydrochloride BiologicalActivity
| Description | Vanoxerine dihydrochloride is a potent and selective dopamine reuptake inhibitor. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Dopamine TransporterResearch Areas >>Neurological Disease |
| References | [1]. Lacerda AE, et al. Vanoxerine: cellular mechanism of a new antiarrhythmic. J Cardiovasc Electrophysiol. 2010 Mar;21(3):301-10. [2]. Mahmud F, et al. Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue. Chaos. 2011 Jun;21(2):023121. |
Chemical & Physical Properties
| Boiling Point | 542.7ºC at 760 mmHg |
|---|---|
| Melting Point | 221 °C |
| Molecular Formula | C28H34Cl2F2N2O |
| Molecular Weight | 523.485 |
| Flash Point | 282ºC |
| Exact Mass | 522.201599 |
| PSA | 15.71000 |
| LogP | 6.80100 |
| InChIKey | MIBSKSYCRFWIRU-UHFFFAOYSA-N |
| SMILES | Cl.Cl.Fc1ccc(C(OCCN2CCN(CCCc3ccccc3)CC2)c2ccc(F)cc2)cc1 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
Articles29
More Articles| Serotonin at the level of the amygdala and orbitofrontal cortex modulates distinct aspects of positive emotion in primates. Int. J. Neuropsychopharmacol. , 1-15, (2011) Impaired top-down regulation of the amygdala, and its modulation by serotonin (5-HT), is strongly implicated in the dysregulation of negative emotion that characterizes a number of affective disorders... | |
| Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats. J. Pharmacol. Exp. Ther. 335(1) , 124-32, (2010) Most life-long drug addiction begins during adolescence. Important structural and functional changes in brain occur during adolescence and developmental differences in forebrain dopamine systems could... | |
| Differential effects of dopamine transporter inhibitors in the rodent Iowa gambling task: relevance to mania. Psychopharmacology 225(3) , 661-74, (2013) The Iowa Gambling Task (IGT) can be used to quantify impulsive and risky choice behaviors in psychiatric patients, e.g., bipolar disorder (BD) sufferers. Although developing treatments for these behav... |
Synonyms
| 1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine dihydrochloride |
| Vanoxerine dihydrochloride |
| Piperazine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2) |
| MFCD00055193 |
| 1-[2-[bis(4-fluorophenyl)methoxy]-ethyl]-4-[3-phenylpropyl]piperazine dihydrochloride |
| 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine,dihydrochloride |
| Vanoxerine hydrochloride |
| Vanoxerine (dihydrochloride) |
