Introduction：Basic information about CAS 1576-37-0|BTS, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BTS |
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| CAS Number | 1576-37-0 | Molecular Weight | 261.33900 |
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| Density | 1.204 g/cm3 | Boiling Point | 419.1ºC at 760 mmHg |
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| Molecular Formula | C14H15NO2S | Melting Point | 115 °C |
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| MSDS | / | Flash Point | 207.3ºC |
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Names
| Name | N-benzyl-4-methylbenzenesulfonamide |
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| Synonym | More Synonyms |
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BTS BiologicalActivity
| Description | BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 ~ 5 μM) and reversibly blocks the gliding motility. IC50 value: 5 uMTarget: Ca2+-stimulated myosin S1 ATPaseBTS also weakens myosin’s interaction with F-actin. BTS is much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II. |
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| Related Catalog | Signaling Pathways >>Cytoskeleton >>MyosinResearch Areas >>Cancer |
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| References | [1]. Cheung A, et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4(1):83-8. |
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Chemical & Physical Properties
| Density | 1.204 g/cm3 |
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| Boiling Point | 419.1ºC at 760 mmHg |
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| Melting Point | 115 °C |
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| Molecular Formula | C14H15NO2S |
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| Molecular Weight | 261.33900 |
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| Flash Point | 207.3ºC |
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| Exact Mass | 261.08200 |
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| PSA | 54.55000 |
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| LogP | 3.94520 |
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| Vapour Pressure | 3.12E-07mmHg at 25°C |
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| Index of Refraction | 1.589 |
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| InChIKey | WTHKAJZQYNKTCJ-UHFFFAOYSA-N |
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| SMILES | Cc1ccc(S(=O)(=O)NCc2ccccc2)cc1 |
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| Storage condition | Desiccate at RT |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- XT5490000
- CHEMICAL NAME :
- p-Toluenesulfonamide, N-benzyl-
- CAS REGISTRY NUMBER :
- 1576-37-0
- BEILSTEIN REFERENCE NO. :
- 2217277
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C14-H15-N-O2-S
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,41,1953
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Safety Information
| RTECS | XT5490000 |
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| HS Code | 2935009090 |
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Customs
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Synonyms
| p-Toluenesulfonamide,N-benzyl |
| N-Tosylbenzylamine |
| N-Benzyl-4-methylbenzenesulfonamide |
| N-Benzyl-p-toluenesulfonamide |
| N-Benzyl-p-toluenesulphonamide |
| N-Benzyl-4-methyl-benzenesulfonamide |
| MFCD00159328 |
| BTS |
