Introduction：Basic information about CAS 84225-95-6|Raclopride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Raclopride |
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| CAS Number | 84225-95-6 | Molecular Weight | 347.24 |
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| Density | 1.288g/cm3 | Boiling Point | 420.3ºC at 760 mmHg |
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| Molecular Formula | C15H20Cl2N2O3 | Melting Point | 54 °C |
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| MSDS | / | Flash Point | 208ºC |
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Names
| Name | 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide |
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| Synonym | More Synonyms |
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Raclopride BiologicalActivity
| Description | Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| Target | Ki: 1.8 nM (D2 receptor), 3.5 nM (D3 receptor), 2400 nM (D4 receptor), 18000 nM (D1 receptor)[1] |
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| References | [1]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70. |
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Chemical & Physical Properties
| Density | 1.288g/cm3 |
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| Boiling Point | 420.3ºC at 760 mmHg |
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| Melting Point | 54 °C |
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| Molecular Formula | C15H20Cl2N2O3 |
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| Molecular Weight | 347.24 |
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| Flash Point | 208ºC |
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| Exact Mass | 346.08500 |
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| PSA | 61.80000 |
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| LogP | 3.25050 |
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| Index of Refraction | 1.563 |
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| InChIKey | WAOQONBSWFLFPE-VIFPVBQESA-N |
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| SMILES | CCN1CCCC1CNC(=O)c1c(O)c(Cl)cc(Cl)c1OC |
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Safety Information
Synonyms
| des-His1-[Glu9]-Glucagon (1-29) amide |
| FLA 870 |
| PRASEODYMIUM(III) TRIFLUOROMETHANESULFONATE |
| 3,5-DICHLORO-N-[[(2S)-1-ETHYL-2-PYRROLIDINYL]METHYL]-2-HYDROXY-6-METHOXYBENZAMIDE |
| (S)-3,5-Dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide |
| 3,5-DICHLORO-N-(((2S)-1-ETHYL-2-PYRROLIDINYL)METHYL)-2-HYDROXY-6-METHOXYBENZAMIDE |
| S(-)-Raclopride L-Tartrate |
| RACLOPRIDE |
| raclopride |
| (S)-(-)-RACLOPRIDE |
