CAS 2113-05-5|1-(3-chlorophenyl)biguanide hydrochloride
Introduction：Basic information about CAS 2113-05-5|1-(3-chlorophenyl)biguanide hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-(3-chlorophenyl)biguanide hydrochloride | ||
|---|---|---|---|
| CAS Number | 2113-05-5 | Molecular Weight | 248.11 |
| Density | 1.49g/cm3 | Boiling Point | 434.1ºC at 760mmHg |
| Molecular Formula | C8H11Cl2N5 | Melting Point | 190-194 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 216.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-(3-chlorophenyl)-1-(diaminomethylidene)guanidine,hydrochloride |
|---|---|
| Synonym | More Synonyms |
BiologicalActivity
| Description | m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease[1]. |
|---|---|
| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
| In Vivo | m-CPBG hydrochloride (80 and 160 nM) 显著减少急性盐负荷引起的水摄入量[1]。 m-CPBG hydrochloride (third ventricle injection; 160 nM) 显著抑制低血容量动物的水摄入[1]。 m-CPBG hydrochloride (third ventricle injection; 320 nM) 减少缺水大鼠的水摄入量[1]。 m-CPBG hydrochloride (central administration） 抑制中枢胆碱能和血管紧张素能通路药理学激活诱导的水摄入[1]。 Animal Model: Wistar male rats[1] Dosage: 80, 160 and 320 nM Administration: Ventricle injection Result: Decreased water intake induced by water deprivation, acute salt load and hypovolemia. |
| References | [1]. Castro L, et al. Central 5-HT(3) receptors and water intake in rats. Physiol Behav. 2002;77(2-3):349-359. |
Chemical & Physical Properties
| Density | 1.49g/cm3 |
|---|---|
| Boiling Point | 434.1ºC at 760mmHg |
| Melting Point | 190-194 °C(lit.) |
| Molecular Formula | C8H11Cl2N5 |
| Molecular Weight | 248.11 |
| Flash Point | 216.3ºC |
| Exact Mass | 247.03900 |
| PSA | 97.78000 |
| LogP | 3.33540 |
| Appearance of Characters | solid | white |
| Vapour Pressure | 9.74E-08mmHg at 25°C |
| InChIKey | FOWAIJYHRWFTHR-UHFFFAOYSA-N |
| SMILES | Cl.NC(N)=NC(N)=Nc1cccc(Cl)c1 |
| Storage condition | Desiccate at RT |
| Water Solubility | H2O: soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 186 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,521,1967
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Endocrine - hyperglycemia
- REFERENCE :
- IJOCAP Indian Journal of Chemistry. (New Delhi, India) V.1-13, 1963-75. Divided into Indian Journal of Chemistry, Section A and Indian Journal of Chemistry, Section B. Volume(issue)/page/year: 1,218,1962
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DU1780000 |
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Synonyms
| 1-(3-Chlorophenyl)biguanide hydrochloride |
| m-Chlorophenylbiguanide hydrochloride |
| MFCD00053019 |
| N-m-Chlorophenylbiguanide hydrochloride |
| m-CPBG hydrochloride |
