CAS 121695-87-2|Sarafotoxin C trifluoroacetate salt
| Common Name | Sarafotoxin C trifluoroacetate salt | ||
|---|---|---|---|
| CAS Number | 121695-87-2 | Molecular Weight | 2515.75000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C103H147N27O37S5 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Sarafotoxin S6c |
|---|---|
| Synonym | More Synonyms |
Sarafotoxin C trifluoroacetate salt BiologicalActivity
| Description | Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Endothelin Receptor |
| Target | Endothelin-B receptor[1] |
| In Vivo | Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1]. Animal Model: Male Wister rats, exposed to 10% O2 [chronic hypoxic (CH) rats] or room air (control rats) for 2 weeks[1] Dosage: 1 pM-1 mM Administration: Result: Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident. Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels. |
Chemical & Physical Properties
| Molecular Formula | C103H147N27O37S5 |
|---|---|
| Molecular Weight | 2515.75000 |
| Exact Mass | 2513.91000 |
| PSA | 1172.52000 |
| InChIKey | LXPHPKVWHQLBBA-UHFFFAOYSA-N |
| SMILES | CCC(C)C(NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CSSCC(N)C(=O)NC(C(C)O)C(=O)NC2CSSCC(NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C(CC(N)=O)NC2=O)C(=O)NC(CC(C)C)C(=O)NC(CC(N)=O)C(=O)NC(Cc2ccccc2)C(=O)N1)C(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles3
More Articles| Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Biochem. Biophys. Res. Commun. 175 , 556-561, (1991) In contrast to endothelin-1 (ET-1) and several of its analogues, sarafotoxin S6c (S6c) was a much more potent inhibitor of [125I]-ET-1 binding in rat hippocampus and cerebellum (Ki approximately 20 pM... | |
| Mechanisms of endothelin-induced venoconstriction in isolated guinea pig mesentery. J. Pharmacol. Exp. Ther. 289 , 762-767, (1999) In the present study, endothelin (ET) agonists and receptor selective antagonists were used to characterize ET receptors mediating constriction in guinea pig mesenteric veins (250-300 micrometers diam... | |
| Influence of endothelins and sarafotoxin 6c and L-NAME on renal vasoconstriction in the anaesthetized rat. Br. J. Pharmacol. 128 , 809-815, (1999) 1. An investigation was performed in pentobarbitone anaesthetized rats to compare the renal vasoconstrictor actions of endothelin-1 (ET-1), endothelin-3 (ET-3) and sarafotoxin 6c and their dependency ... |
Synonyms
| MFCD00133969 |
| SRTX-c |
| Sarafotoxin S 6c |
| Sarafotoxin 6c |
