CAS 151342-35-7|(S)-Ro 32-0432 free base

Introduction：Basic information about CAS 151342-35-7|(S)-Ro 32-0432 free base, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (S)-Ro 32-0432 free base BiologicalActivity
3. Chemical & Physical Properties

Common Name	(S)-Ro 32-0432 free base
CAS Number	151342-35-7	Molecular Weight	452.55
Density	/	Boiling Point	711.9ºC at 760 mmHg
Molecular Formula	C₂₈H₂₈N₄O₂	Melting Point	/
MSDS	/	Flash Point	384.3ºC

Names

Name	bisindolylmaleimide X

(S)-Ro 32-0432 free base BiologicalActivity

Description	(S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research[1][2].
Related Catalog	Signaling Pathways >>Epigenetics >>PKCResearch Areas >>Inflammation/ImmunologySignaling Pathways >>TGF-beta/Smad >>PKC
References	[1]. A M Birchall, et al. Ro 32-0432, a Selective and Orally Active Inhibitor of Protein Kinase C Prevents T-cell Activation. J Pharmacol Exp Ther. 1994 Feb;268(2):922-9. [2]. Thakur Gurjeet Singh, et al. Ro 32-0432 Attenuates Mecamylamine-Precipitated Nicotine Withdrawal Syndrome in Mice. Naunyn Schmiedebergs Arch Pharmacol. 2013 Mar;386(3):197-204.

Description

(S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S)-Ro 32-0432 free base for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research[1][2].

Related Catalog

Signaling Pathways >>Epigenetics >>PKCResearch Areas >>Inflammation/ImmunologySignaling Pathways >>TGF-beta/Smad >>PKC

References

[1]. A M Birchall, et al. Ro 32-0432, a Selective and Orally Active Inhibitor of Protein Kinase C Prevents T-cell Activation. J Pharmacol Exp Ther. 1994 Feb;268(2):922-9.

[2]. Thakur Gurjeet Singh, et al. Ro 32-0432 Attenuates Mecamylamine-Precipitated Nicotine Withdrawal Syndrome in Mice. Naunyn Schmiedebergs Arch Pharmacol. 2013 Mar;386(3):197-204.

Chemical & Physical Properties

Boiling Point	711.9ºC at 760 mmHg
Molecular Formula	C₂₈H₂₈N₄O₂
Molecular Weight	452.55
Flash Point	384.3ºC
Exact Mass	488.19800
PSA	59.27000
LogP	4.95500
Vapour Pressure	4.11E-20mmHg at 25°C
InChIKey	FXGHOAZJQNLNFD-KRWDZBQOSA-N
SMILES	CN(C)CC1CCn2c(c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c3ccccc32)C1

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